Synthesis and Antitumor Activity of Fused Quinoline Derivatives. II. Novel 4- and 7-Hydroxyindolo-[3,2-b]quinolines
スポンサーリンク
概要
- 論文の詳細を見る
Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose=50mg/kg, the median survival time of treated group/control group (T/C)>330%, cure=5/6).
- 社団法人日本薬学会の論文
- 1992-02-25
著者
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竹内 靖雄
岡山大学薬学部
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竹内 靖雄
Faculty of Pharmaceutical Sciences, Okayama University
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橋垣 国子
Faculty of Pharmaceutical Sciences, Okayama University
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大和 正利
Faculty of Science, Okayama University of Science
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張 明栄
Faculty of Pharmaceutical Science, Okayama University
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大和 正利
Faculty Of Pharmaceutical Sciences Okayama University
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大和 正利
Faculty Of Science Okayama University Of Science
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竹内 靖夫
Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center
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張 明栄
Faculty Of Pharmaceutical Sciences Okayama University
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橋垣 国子
Faculty Of Pharmaceutical Sciences Okayama University
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橋垣 國子
Faculty Of Pharmaceutical Sciences Okayama University
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