Synthesis of 3-Substituted Benzoxazoline-2-thiones

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概要

• 論文の詳細を見る

• Several methods for the preparations of 3-substituted benzoxazoline-2-thiones (1) were examined. Method B via the thiation of 3-substituted benzoxazolin-2-one (5) with phosphorus pentasulfide was found to be applicable to the preparation of most analogs of 1,with a few exceptions. Method C via the cyclization of 2-(alkylamino) phenol (7) with potassium O-methyldithiocarbonate was suitable for the preparation of analogs with a group sensitive to high temperature or with an aryl-(including aromatic heterocyclic ring) methyl group. In addition, the reaction of benzoxazoline-2-thione (2) with acetals such as 1-ethoxy-isochroman, 2-ethoxytetrahydrofuran, and 2-ethoxytetrahydropyran, or with Michael acceptors such as 2,3-dihydrofuran and 2H-3,4-dihydropyran, gave 3-substituted benzoxazoline-2-thione (1d-f).

• 社団法人日本薬学会の論文
• 1983-05-25

著者

• 竹内 靖雄

  岡山大学薬学部

• 竹内 靖雄

  Faculty of Pharmaceutical Sciences, Okayama University

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 服部 京子

  Faculty of Pharmaceutical Sciences, Okayama University

• 室賀 恵一子

  Faculty of Pharmaceutical Sciences, University

• 広田 喬

  Faculty of Pharmaceutical Sciences, University

• 服部 京子

  Faculty Of Pharmaceutical Sciences Okayama University

• 廣田 喬

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 竹内 靖夫

  Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center

• 広田 喬

  岡山大学 薬

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

• 室賀 恵一子

  Faculty Of Pharmaceutical Sciences University

• 広田 喬

  Faculty Of Pharmaceutical Sciences Okayama University

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