Benzylcarbonyl化合物とFormamideとの反応(第6報) : Isoquinoline誘導体の生成

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概要

• 論文の詳細を見る

• All the starting materials use in the previous work on were benzylcarbonyl compounds with a cyano group in the α-position. The CN function was favorably involved in this reaction to lead to a pyrimidine. Experiments with compounds without a CN group were undertaken in the hope that they may furnish the desired isoquinolines. Heating of 3,4-methylenedioxyphenylacetone (Ia) or 3,4-dimethoxyphenylacetone (Ib) with formamide and phosphoryl chloride gave the corresponding isoquinolines (II) as expected. However, homopiperonal (III) gave a naphthalene derivative (IV), benzoin (Va) or piperoin (Vb) afforded an oxazole derivative (VI), anisoin (Vc) formed an imidazole derivative (VII), and desoxybenzoin (VIII) was led to 4,5-diphenylpyrimidine (IX) under similar reaction conditions.

• 公益社団法人日本薬学会の論文
• 1970-01-25

著者

• 廣田 喬

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  第一薬科大学

• 勝瀬 良樹

  熊本大学薬学部

関連論文

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• Synthesis and Antitumor Activity of Fused Quinoline Derivatives
• The Wittig Reaction of Benzofuran-2,3-diones
• Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners. I
• A Practical Synthetic Method for β-Ketoesters from Ketones
• One-Flask Synthesis of Sulfides from Alcohols and Alkyl Halides Using Benzoxazoline-2-thione
• A New Method for the Preparation of 2-Alkoxybenzoxazoles
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