Alkoxycarbonylmethylation of(3R, 10bS)-3-Phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline

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概要

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• As part of a series of studies on synthesis of chiral 1-alkyltetrahydroisoquinolines, asymmetric synthesis of 1-alkoxycarbonylmethyl-1,2,3,4-tetrahydroisoquinolie (IV) was investigated. Two synthetic approaches using intermolecular and intramolecular Reformatsky-type reactions from (3R, 10bS)-3-phenyl-2,3,5,6-tetrahydro-10bH-oxazolo[2,3-a]isoquinoline (1) were attempted, but high stereoselectivity could not be obtained. For the purpose of determining the absolute structures of the compounds (2,3) obtained by the Reformatsky-type reactions, transformation of 3a to a chiral 1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine (14) was investigated.

• 社団法人日本薬学会の論文
• 1994-04-15

著者

• 原山 尚

  Faculty of Pharmaceutical Sciences, Chiba University

• 竹内 靖雄

  岡山大学薬学部

• 原山 尚

  岡山大学薬学部

• 竹内 靖雄

  Faculty of Pharmaceutical Sciences, Okayama University

• 鎌田 善雄

  Faculty of Pharmaceutical Sciences, Okayama University

• 西村 浩司

  Faculty of Pharmaceutical Sciences, Okayama University

• 西岡 弘美

  Faculty of Pharmaceutical Sciences, Okayama University

• 西川 昌代

  Faculty of Pharmaceutical Sciences, Okayama University

• 橋垣 国子

  Faculty of Pharmaceutical Sciences, Okayama University

• 大和 正利

  Faculty of Science, Okayama University of Science

• 原山 尚

  Faculty Of Pharmaceutical Sciences Kyoto University

• 西岡 弘美

  岡山大学機器分析センター

• 大和 正利

  Faculty Of Pharmaceutical Sciences Okayama University

• 大和 正利

  Faculty Of Science Okayama University Of Science

• 竹内 靖夫

  Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center

• 鎌田 善雄

  Faculty Of Pharmaceutical Sciences Okayama University

• 西村 浩司

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 国子

  Faculty Of Pharmaceutical Sciences Okayama University

• 橋垣 國子

  Faculty Of Pharmaceutical Sciences Okayama University

• 西川 昌代

  Faculty Of Pharmaceutical Sciences Okayama University

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