CESIUM FLUORIDE-MEDIATED CLAISEN REARRANGEMENT OF ARYL PROPARGYL ETHER AND ITS APPLICATION TO THE SYNTHESIS OF CHELERYTHRINE
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概要
- 論文の詳細を見る
In the presence of cesium fluoride, the Claisen rearrangement of aryl propargyl ethers selectively provided 2-methylbenzofurans, which was successively treated with osmium tetroxide, periodic acid and 5% sodium hydroxide to give salicylaldehydes in good yields. The method was used to synthesize chelerythrine (2) via the common intermediate (8) prepared by the two routes as shown in Chart 3.
- 社団法人日本薬学会の論文
- 1990-06-25
著者
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鈴木 雅博
Hanno Research Center Chemistry Lab. Taiho Pharmaceutical Co. Ltd.
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石井 永
Faculty of Pharmaceutical Sciences, Chiba University
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石川 勉
Faculty of Pharmaceutical Sciences, Chiba University
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武田 直
Faculty of Pharmaceutical Sciences, Chiba University
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鈴木 雅博
Faculty of Pharmaceutical Sciences, Chiba University
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原山 尚
Faculty of Pharmaceutical Sciences, Chiba University
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植木 聡
Faculty of Pharmaceutical Sciences, Chiba University
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石川 勉
千葉大薬
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石川 勉
千葉大院薬
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原山 尚
Faculty Of Pharmaceutical Sciences Kyoto University
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石井 永
Faculty Of Pharmaceutical Sciences Chiba University
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Ishii H
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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武田 直
Faculty Of Pharmaceutical Sciences Chiba University
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植木 聡
Faculty Of Pharmaceutical Sciences Chiba University
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