Fischer Indolization of Ethyl Pyruvate 2-[2-(Trifluoromethyl)phenyl]-phenylhydrazone and New Insight into the Mechanism of the Goldberg Reaction. (Fischer Indolization and Its Related Compounds. XXVI)
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概要
- 論文の詳細を見る
The Fischer indolization of ethyl pyruvate 2-[2-(trifluoromethyl)phenyl]phenylhydrazone (5) gave two indolic products, ethyl 7-(trifluoromethyl)-1-phenylindole-2-carboxylate (12) as a minor product and ethyl 1-[2-(trifluoromethyl)phenyl]indole-2-carboxylate (13) as a major product. This result shows that the Fischer indolization occurred on the more electron-rich phenyl group. In the Goldberg reaction to prepare 13 from ethyl indole-2-carboxylate (15) and o- (21) or m-bromo-α, α, α-trifluotoluene (23), it was found that Goldberg reaction proceeds via a benzyne mechanism, at least in part, in a sterically crowded situation.
- 社団法人日本薬学会の論文
- 1995-08-15
著者
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石井 永
Faculty of Pharmaceutical Sciences, Chiba University
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渡辺 敏子
千葉大院薬
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渡辺 敏子
School Of Pharmaceutical Sciences Toho University
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石井 永
Faculty Of Pharmaceutical Sciences Chiba University
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村上 泰興
School of Pharmaceutical Sciences, Toho University
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萩原 孝夫
Faculty of Pharmaceutical Sciences, Chiba University
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秋山(旧姓近藤) 洋子
Faculty of Pharmaceutical Sciences, Chiba University
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秋山(旧姓近藤) 洋子
Faculty Of Pharmaceutical Sciences Chiba University
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村上 泰興
東邦大・薬
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村上 泰興
School Of Pharmaceutical Science Toho University
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萩原 孝夫
Faculty Of Pharmaceutical Sciences Chiba University
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