ミカン科植物成分の研究(第21報)イワザンショウXanthoxylum arnottianum MAXIM.の成分その2幹の木質部の検索

概要

論文の詳細を見る
Four alkaloids, 11 coumarins ; and 2 neutral components were isolated from the xylem of the stem of Xanthoxylum arnottianum MAXIM. (Japanese name "Iwa-zansho"). Three of the alkaloids were confirmed with the known furoquinoline alkaloids, dictamnine (11), robustine (15), and haplopine (19). A new water-soluble quaternary base, Base II, was isolated as its picrate, C_<11>H_<16>O_2N^+・C_6H_2O_7N_3-, mp 256-260°, which was assumed to be a simple N, N-dimethyltetrahydroisoquinolinium derivative from its molecular formula. In order to compare the physical constants, 6,7-dihydroxy-(23), mp 242-244°, and 7,8-dihydroxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium picrate (24), mp 181 -184°, were synthesized. Five coumarins, (R)-(-)-columbianetin (4), marmesin (5), rutaretin methyl ether (9), osthenol (8) and arnottinin (10), and β-sitosterol (1) and l-asarinin (2) were obtained as common consituents in the root of the same plant together with two other known coumarins, xanthyletin (3) and psoralen (18), as sole components of the stem. Peucedanol methyl ether (14), a methylated product of naturally occurring peucedanol, was isolated for the first time from a natural source. Three other new coumarins, arnottianin (12), C_<15>H_<16>O_5,mp 197 -198°; coumarin I (6), C_<14>H_<10>O_3,mp 180-183°, and coumarin II (7), C_<15>H_<12>O_4,mp 140-145°, were characterized.
社団法人日本薬学会の論文
1974-03-25