アミン-N-オキシドの関与する反応(第3報)ピリミジン, キナゾリン同族体とピリジン-N-オキシドとの反応

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Dehydrogenition-condensation reaction was carried out on the following compounds using palladium-carbon catalyst added with platinum (Pd/Pt-C) and pyridine 1-oxide, (II), under the same conditiohs as reported previously.^<1)> The cmopounds examined were pyrimidine (I), 4-methylpyrimidine (VII), 4,6-dimethylpyrimidine (X), and 6,7-dimethoxyquinazoline (XI). Various compounds were thereby formed (Charts 1 and 2), and III, V, VI, and VIII are new compounds. I underwent selective dehydrogenation-condensation at position a to the ring nitrogen, not at 2-position between the two nitrogen atoms, while the reaction did not progress in X and XI. The dehydrogenation-condensation reaction of I using only the palladium-carbon catalyst, without pyridine 1-oxide, resulted in a poor yield, indicating that pyridine 1-oxide gives a good effect on this reaction.
社団法人日本薬学会の論文
1974-01-25