アミンN-オキシドの関与する反応(第12報)フェロインまたはクプロイングループを有する非対称型化合物の合成

概要

論文の詳細を見る
Synthesis of asymmetric compounds having a ferroin or cuproin group, such as 2,2'-dipyridyls (III) like 3,4'-dimethyl-2,2'-dipyridyl, derivatives of 2-(2-pyridyl) quinoline (VI) and asymmetric 2,2'-diquinolinyl (XIII), and derivatives of pyridylpyridazine (XII), pyridylpyrazine, and pyridylquinoxaline may be carried out by dehydrogenative condensation of aromatic amine N-oxides using a platinized palladium-carbon catalyst, and examinations were made to see which of I and II should be derived to their N-oxide. In the syntheses of III and XIII, reaction should be carried out by derivation of a more reactive compound to its N-oxide. For the synthesis of VI, better yield is obtained by derivation of pyridine to its N-oxide rather than quinoline, although reaction of quinoline N-oxide gives VI preferencially but in a small yield, with little formation of other by-products. XII is obtained by the reaction of pyridine with pyridazine N-oxides but, in the case of pyrazine and quinoxaline, the objective compound is obtained only when quinoxaline is reacted with pyridine N-oxide.
社団法人日本薬学会の論文
1979-12-25