Studies on the Chemical Constituents of Rutaceous Plants. XLIX. Development of a Versatile Method for the Synthesis of Antitumor-Active Benzo [c] phenanthridine Alkaloids. (1). Preparation of Various 2,4-Bisaryl-4-oxobutyronitriles and 2,4-Bisaryl-4-oxobu

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For the sake of establishment of a versatile synthetic method for benzo [c] phenanthridine alkaloids, improvement of the Robinson synthetic method was examined. Thirteen chalcones (7a-m) were prepared by condensation of two acetophenone derivatives (15 and 16) with eleven benzaldehyde derivatives (19a-k) as fundamental starting materials. Hydrocyanation of these chalcones (7a-l) except one (7m) gave the corresponding 2,4-bisaryl-4-oxobutyronitriles (8a-l). Eleven 2,4-bisaryl-4-oxobutyramides (9a-k) were also prepared.
社団法人日本薬学会の論文
1983-09-25