77 マイシナミシンの構造研究(6)

概要

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Mycinamicins, a new group of basic 16-membered macrolide antibiotics, have been obtained from Micromonospora griseorubida sp. nov., and named as mycinamicin in I, II, III, IV and V, respectively. They were characterized as in Table 1 and were composed of an amino sugar, desosamine, and a neutral sugar, mycinose or javose. When mycinamicin IV and V were heated in 0.2 N-HCl (pH 2.0) at 90℃ for 4 days, new products were formed and purification of this products by silica gel chromatography afforded IX, X, XI and XII, XIII, XIV, respectively. The isolated aglycone moieties (IX and XII) were different from those of well known similar macrolide antibiotics, namely, magnamycin, tylosin, chalcomycin and juvenimicin A_2 types. In order to investigate the structural relationships of mycinamicin I and II to IV and V, we studied their de-epoxidation (CrCl_2 in N-H_2SO_4). Reaction products from I and II were completely identical with natural mycinamicin IV and V, in all respects. The ^<13>C-NMR spectra of mycinamicins also supported the structures I, II, III, IV and V.
天然有機化合物討論会の論文
1980-09-10