Studies on the Constituents of Seeds of Pachyrrhizus erosus and Their Anti : Herpes Simplex Virus (HSV) Activities

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概要

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• Studies on the chemical constituents of the seeds of Pachyrrhizus erosus (Leguminosae) resulted in the isolation of nine known components: five rotenoids [dolineone (3), pachyrrhizone (5), 12a-hydroxydolineone (7), 12a-hydroxypachyrrhizone (9), and 12a-hydroxyrotenone (2)], two isoflavonoids [neotenone (4) and dehydroneotenone (8)], one phenylfuranocoumarin [pachyrrhizine (6)], and a monosaccharide (dulcitol). The full ^1H-and ^<13>C-NMR assignments for the isolated products except a sugar, including revision of previous assignments in the literature, are reported. Moderate anti herpes simplex virus (HSV) activity was observed in 12a-hydroxydolineone (7) and 12a-hydroxypacbyrrhizone (9) among the isolated products.

• 公益社団法人日本薬学会の論文
• 2002-04-01

著者

• 渡辺 敏子

  School Of Pharmaceutical Sciences Toho University

• ISHIKAWA TSUTOMU

  Graduate School of Pharmaceutical Sciences, Chiba University

• RUANGRUNGSI Nijsiri

  Faculty of Pharmaceutical Sciences, Chulalongkorn University

• WATANABE Toshiko

  Graduate School of Pharmaceutical Science, Chiba University

• Watanabe Toshifumi

  Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries

• Ishikawa Tsutomu

  Dep. Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Univ.

• Ishikawa Tsutomu

  Graduate School Of Pharmaceutical Sciences Chiba University

• Watanabe Toshiko

  Graduate School Of Pharmaceutical Sciences Chiba University

• Watanabe Toshiko

  Faculty Of Pharmaceutical Sciences Josai University

• Watanabe Toshihiro

  Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.

• Ishikawa T

  Graduate School Of Pharmaceutical Sciences Chiba University

• PHRUTIVORAPONGKUL Ampai

  Faculty of Pharmaceutical Sciences, Chulalongkorn University

• LIPIPUN Vimolmas

  Faculty of Pharmaceutical Sciences, Chulalongkorn University

• Lipipun Vimolmas

  Faculty Of Pharmaceutical Sciences Chulalongkorn University

• Phrutivorapongkul Ampai

  Faculty Of Pharmaceutical Sciences Chulalongkorn University

• Ishikawa Tsutomu

  Graduate School Of Pharmaceutical Sciences Chiba Univ.

• Ruangrungsi Nijsiri

  Faculty Of Pharmaceutical Sciences Chulalongkorn University

• Watanabe Toshiko

  Graduate School Of Pharmaceutical Science Chiba University

• Ishikawa Toshihisa

  Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• Ishikawa Toshihisa

  Graduate School of Pharmaceutical Sciences, Chiba University

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