Control of Spermidine and Spermine Levels in Rat Tissues by trans-4-Methylcyclohexylamine, a Spermidine-Synthase Inhibitor(Analytical Biochemistry)

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概要

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• In rat tissues, a decrease in spermidine, accompanied by an increase in spermine was induced by the oral administration (once daily for either 1 week or 1 month) of trans-4-methylcyclohexylamine (4MCHA), a spermidine synthase inhibitor. This is similar to the changes observed in polyamine content when cell growth is arrested. The body-weight gain of the rats tended to decrease with increasing doses of 4MCHA. A decrease in spermidine, combined with a moderate increase in spermine, was observed dose-dependently in all of the tissues tested, with a relatively fast clearance of 4MCHA. Manipulating the polyamine content of tissues, by daily administration of 100 μmol 4MCHA for 1 week, made it possible to estimate the effects of simultaneously added spermidine or spermine on endogenous polyamine contents. The altered polyamine levels, obtained after daily administration for 1 week, were maintained during the extended 1-month period, with growth-dependent alteration. The results show it is possible to produce experimental rats with a higher spermine : spermidine ratio than control rats to investigate the physiological significance of spermidine downregulation and spermine upregulation in vivo.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• Xu Yong

  Institute Of Chemical & Molecular Technology Qingdao University Of Science And Technology

• Xu Yong

  城西大学 薬 薬品分析化学

• SHIRAHATA Akira

  Faculty of Pharmaceutical Sciences, Josai University

• SAMEJIMA Keijiro

  Faculty of Pharmaceutical Sciences, Josai University

• Shirahata A

  Fac. Of Pharmaceutical Sciences Josai Univ.

• Shirahata Akira

  Faculty Of Pharmaceutical Science Josai University

• KOBAYASHI Masaki

  Faculty of Engineering, Chubu University

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Josai University

• WATANABE Toshiko

  Faculty of Pharmaceutical Sciences, Josai University

• TATEMORI Minoru

  Faculty of Pharmaceutical Sciences, Josai University

• GODA Hitomi

  Faculty of Pharmaceutical Sciences, Josai University

• NIITSU Masaru

  Faculty of Pharmaceutical Sciences, Josai University

• Tatemori Minoru

  Faculty Of Pharmaceutical Sciences Josai University

• Samejima Keijiro

  Faculty Of Pharmaceutical Sciences Josai University

• Samejima K

  Faculty Of Pharmaceutical Sciences Josai University

• Watanabe Toshiko

  Faculty Of Pharmaceutical Sciences Chiba University

• Watanabe Toshiko

  Faculty Of Pharmaceutical Sciences Josai University

• 鮫島 啓二郎

  Faculty Of Pharmaceutical Sciences Josai University

• Goda H

  Faculty Of Pharmaceutical Sciences Josai University

• Niitsu M

  Josai Univ. Saitama Jpn

• Niitsu Masaru

  Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Josai University

• Niitsu Masaru

  Faculty Of Pharmaceutical Sciences Josai University

• Shirahata Akira

  Lab. Of Cellular Physiology Dep. Of Clinical Dietetics And Human Nutrition Fac. Of Pharmaceutical Sc

• Kobayashi Masaki

  Faculty Of Engineering Soka University

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