Syntheses of Tertiary Tetraamines and Quaternary Pentaamines with Three and Four Methylene Chain Units
スポンサーリンク
概要
- 論文の詳細を見る
Tertiary tetraamines and quaternary pentaamines composed of aminopropyl and/or aminobutyl groups were synthesized as authentic samples for the identification of naturally occurring branched polyamines. Four tertiary tetraamines were obtained by alkylating the free secondary amine group of diphthaloyl derivatives of sym-norspermidine or sym-homospermidine with N-(3-bromopropyl)phthalimide or N-(4-bromobutyl)phthalimide in the presence of KF-Celite. Five quaternary pentaamines were obtained by fusing triphthaloyl derivatives of the tertiary tetraamines with an excess amount of N-(3-iodopropyl)phthalimide or N-(4-iodobutyl)phthalimide. The present methods are simple and achieved high yields. The ^<13>C-NMR spectra of these branched polyamines were recorded in D_2O as fully protonated forms, and all ^<13>C chemical shifts were assigned consistently.
- 公益社団法人日本薬学会の論文
- 1992-11-25
著者
-
新津 勝
城西大学薬学部
-
鮫島 啓二郎
Faculty of Pharmaceutical Sciences, University of Tokyo Hongo-7-3-1, Bunkyo-ku, Tokyo, Japan, 113
-
新津 勝
Faculty of Pharmaceutical Sciences, Josai University
-
Samejima K
Faculty Of Pharmaceutical Sciences Josai University
-
鮫島 啓二郎
Faculty Of Pharmaceutical Sciences Josai University
-
佐野 平雄
Faculty of Pharmaceutical Sciences, Josai University
-
佐野 平雄
Faculty Of Pharmaceutical Sciences Josai University
関連論文
- Formation of Spermidine or Norspermidine from Synthetic Diacetylpolyamines by Acetylpolyamine Oxidase in Cultured Cells(Biochemistry)
- きのこの主ポリアミン成分としてのスペルミンとアグマチンの分布--きのこのポリアミン分析(3)
- きのこの主ポリアミン成分としてのスペルミンとアグマチンの分布 : きのこのポリアミン分析III
- Partial purification of cytotoxic substances from Moxa extract
- 1-(2-ピリジルアゾ)-2-ナフトールによるクロム(III)の溶媒抽出に及ぼす過塩素酸イオンの効果
- A New Ultra-micro Microbioassay
- Simultaneous Determination of Endogenous and Orally Administered 15N-Labeled Polyamines in Rat Organs
- Syntheses of [13C, 15N]-Labeled Polyamines
- Fate of Orally Administered 15N-Labeled Polyamines in Rats Bearing Solid Tumors
- Measurements of Macromolecule-Bound and Ultra-FiltrablePolyamines in Rat Liver Homogenized without Buffer
- Preparation and Usefulness of Some Fluorogenic Substrates for Assay of Arginyl-tRNA-Protein Transferase byHPLC
- Syntheses of [5,8-^C_2]- and [1,12-C_2]Spermine Using Potassium [^C]Cyanide as the ^C Source
- Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases
- Mass Spectrometric Separation and Determination of N1,N12-Diacetylspermine in the Urine of Cancer Patients
- A Gas Chromatographic Determination Method of 5-Chloro-7-iodo-8-quinolinol and Its Conjugates in Biological Fluids
- Synthesis of 5-Chloro-7-iodo-8-quinolinol Sulfate
- Bifidus Factors in Carrot. I. Purification and Some Properties
- Inhibition of Putrescine Aminopropyltransferase Influences Rat Liver Regeneration(Analytical Biochemistry)
- Control of Spermidine and Spermine Levels in Rat Tissues by trans-4-Methylcyclohexylamine, a Spermidine-Synthase Inhibitor(Analytical Biochemistry)
- Mammalian Spermidine Synthase : Identification of Cysteine Residues and Investigation of the Putrescine Binding Site(Analytical Biochemistry)
- Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases
- Fate of Orally Administered ^15N-LabeIed Polyamines in Rats Bearing Solid Tumors
- Measurements of Macromolecule-Bound and Ultra-Filtrable Polyamines in Rat Liver Homogenized without Buffer
- Primary Structure of Rat Spermidine Synthase : An Example of Refining the cDNA-Derived Amino Acid Sequence
- Determination of Covalently Bound Hypusine and Deoxyhypusine to Protein Using Submilligram of Protein Samples by HPLC
- Specific Depletion of Spermidine and Spermine in HTC Cells Treated with Inhibitors of Aminopropyltransferases^1
- マメ科種子のポリアミン構成と発芽時のポリアミン変動
- 数種のδおよびεプロテオバクテリアにおけるポリアミン構成
- Enzymatic Aminopropylation of Certain Secondary Amines
- A Simpler Synthesis of D-Pantothenic Acid 4'-Phosphate
- Primary Structure of Rat Spermidine Synthase: AnExample of Refining the cDNA-Derived Amino AcidSequence
- Antagonistic Effect of N - (3 - Aminopropyl)cyclohexylamine on Neurotrophic Action of Spermine in Primary Cultured Rat Hippocampal and Cerebellar Neurons
- Structural Requirement for Neurotrophic Activity of Spermine in Cultured Rat Hippocampal Neurons
- Mass Spectrometric Separation and Determination of N^1,N^-Diacetylspermine in the Urine of Cancer Patients
- スペルミジン過剰蓄積細胞における核成分の変化
- Relative Reactivities of Histamine and Indoleamines with Acetaldehyde
- Large production of an aromatic amine, 2-phenylethylamine, in a psychrophilic marine bacterium,Psychroflexus torquis
- Occurrence of aminopropylhomospermidine as themajor cellular polyamine in a halophilic, phototrophicalpha proteobacterium, Rhodothalassium salexigens
- Occurrence of tertiary branched tetraamines in two aquaticplants
- Production of 2-phenylethylamine by Decarboxylationof L-Phenylalanine in Alkaliphilic Bacillus cohnii
- IDENTIFICATION OF N^4-(2-PROPENAL) SPERMIDINE AS A MAJOR REACTION PRODUCT OF MALONDIALDEHYDE AND SPERMIDINE
- Syntheses of Tertiary Tetraamines and Quaternary Pentaamines with Three and Four Methylene Chain Units
- Analayses of Variously ^N-Enriched Spermidines during Growth of Candida coidinii Cultured with ^N-Enriched Ammonium Sulfate and α-^N-Enriched L-Ornithine
- Syntheses of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals
- Studies on Inhibition of Enzymatic Arginyltransfer Reaction
- Arginyl-tRNA-Protein Transferase Activities in CrudeSupernatants of Rat Tissues
- ポリアミンの調節を目指した方法論の開発
- アスパラギン酸アナログによるアルギニルトランスフェラーゼの阻害効果の検討
- Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. III. Metabolites of 4-Dimethylaminoazobenzene in Rat Bile and Influence of DAB Feeding on their Amounts
- A Probable Structure of the Bifidus Factor in Carrot Root
- TRANS-4-METHYLCYCLOHEXYLAMINE, A POTENT NEW INHIBITOR OF SPERMIDINE SYNTHASE
- Metabolites of p-Dimethylaminoazobenzene in Rat Bile
- きのこにおけるポリアミンの分布とその成分構成
- きのこのポリアミンとしてのホモスペルミジンとカナバルミンの存在
- P-0522 小児の乳酸菌製剤服薬時の保存方法に関する検討(一般演題 ポスター発表,調剤・処方鑑査・リスクマネジメント,Enjoy Pharmacists' Lifestyles)
- シアノバクテリアにおける菌体内ポリアミン成分構成
- きのこにおける2-フェニルエチルアミン(β-フェネチルアミン)の検出と分布 : きのこのポリアミン分析IV
- MICROBIOLOGICAL ULTRAMICRO DETERMINATION OF PANTOTHENIC ACID, BIOTIN, AND NICOTINIC ACID WITH AMPLIFIED CULTIVATION
- きのこにおける2-フェニルエチルアミン(β-フェネチルアミン)の検出と分布 : きのこのポリアミン分析IV
- Metabolism of 4-Dimethylaminoazobenzene and Related Compounds. IV. Metabolites of o-Aminoazotoluene in Rat Bile.
- みんなでお薬かるた
- 日-P2-136 お茶を摂取している抗血栓剤ワルファリンカリウム服用患者への服薬指導について(外来薬剤師業務,ポスター発表,一般演題,再興、再考、創ろう最高の医療の未来)