Inhibition of Putrescine Aminopropyltransferase Influences Rat Liver Regeneration(Analytical Biochemistry)

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概要

• 論文の詳細を見る

• A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd: spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as a percentage index of remnant liver weight to body weight, correlated well with a decrease of the spd: spm value, with a correlation coefficient of 0.952 for the remnant livers on day 3 after partial hepatectomy. The decrease in recovery rate could be explained by a prolonged cell cycle based on the data of the proliferating cell nuclear antigen labelling index and mitotic cell index in both livers of day 2 and day 3 after partial hepatectomy. The results presented here will give a new aspect in the field of polyamine regulation to control cell growth in vivo.

• 公益社団法人日本薬学会の論文
• 2006-05-01

著者

• TAKAO Koichi

  Faculty of Pharmaceutical Sciences, Josai University

• SUGITA Yoshiaki

  Faculty of Pharmaceutical Sciences, Josai University

• SAMEJIMA Keijiro

  Faculty of Pharmaceutical Sciences, Josai University

• KOBAYASHI Masaki

  Faculty of Engineering, Chubu University

• Takao Koichi

  Faculty Of Pharmaceutical Sciences Josai University

• Takao Koichi

  Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Josai University

• Nakae Dai

  Sasaki Institute Sasaki Foundation

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Josai University

• Takahashi M

  Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation

• SHIOTA Yasuo

  Faculty of Pharmaceutical Sciences, Josai University

• TAKAHASHI Masakazu

  Sasaki Institute, Sasaki Foundation

• Shiota Yasuo

  Faculty Of Pharmaceutical Sciences Josai University

• Sugita Yoshiaki

  Faculty Of Pharmaceutical Sciences Josai University

• Samejima Keijiro

  Faculty Of Pharmaceutical Sciences Josai University

• Samejima K

  Faculty Of Pharmaceutical Sciences Josai University

• Tada M

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 鮫島 啓二郎

  Faculty Of Pharmaceutical Sciences Josai University

• Takahashi Masakazu

  Sasaki Inst.

• Tsukatani Masaki

  Faculty Of Pharmaceutical Science Kobe Gakuin University

• Kobayashi Masaki

  Faculty Of Engineering Soka University

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