Distribution of Dolichol in the Serum and Relationships between Serum Dolichol Levels and Various Laboratory Test Values(Biochemistry)
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概要
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We examined the correlations between serum dolichol levels and laboratory test parameters in patients affected by disease, as well as the distribution of dolichol in sera from patients with hyperbetalipoproteinemia and hyperalphalipoproteinemia. Serum dolichol was evaluated by a reverse-phase HPLC method. After centrifugation, the serum dolichol found in healthy controls was mainly associated with medium-sized particles of the highdensity lipoprotein (HDL) fraction. For patients with hyperbetalipoproteinemia, serum dolichol was also associated with the medium HDL fractions. However, for hyperalphalipoproteinemia patients the levels of large HDL and serum dolichol were increased, and serum dolichol was mainly associated with the large HDL fraction. On laboratory tests of components, the dolichol level was not correlated with the values for markers of the liver and biliary system, with the values of renal function markers, with creatine kinase activity, amylase activity or uric acid concentration, but was correlated with total cholesterol, HDL-cholesterol and apoA-I concentrations, and with lactate dehydrogenase (LDH) activity. These results suggest that serum dolichol exclusively localized in HDL, and in subpopulation, that in normocholesterolemia or hyperbeta-cholesterolemia is associated with HDL_3, which is small sized and high density HDL, however, that in hyperalphacholesterolemia is associated with HDL_2, which is large sized and lower density HDL.
- 公益社団法人日本薬学会の論文
- 2008-03-01
著者
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Hashimoto Fumie
Faculty of Pharmaceutical Sciences, Josai University
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KAWAMURA Mitsunobu
Department of Internal Medicine, Tokyo Teishin Hospital
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Kawamura Mitsunobu
Department Of Internal Medicine Tokyo Teishin Hospital
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SHIOTA Yasuo
Faculty of Pharmaceutical Sciences, Josai University
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Shiota Yasuo
Faculty Of Pharmaceutical Sciences Josai University
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MIYAZAKI Shigeru
Department of Internal Medicine, Kidney Center, Shinrakuen Hospital
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Miyazaki Shigeru
Department Of Internal Medicine Tokyo Teishin Hospital
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KIYOTA Kengo
Faculty of Pharmaceutical Sciences, Josai University
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KOBAYASHI Teruaki
Departmentof Clinical Laboratory, Tokyo Teishin Hospital
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KANO Shojiro
Departmentof Clinical Laboratory, Tokyo Teishin Hospital
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MATSUSHIMA Teruhiko
Department of Internal Medicine, Tsukuba Memorial Hospital
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UCHINO Katsuyoshi
Departmentof Pharmacy, Tokyo Teishin Hospital
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HAYASHI Hidenori
Faculty of Pharmaceutical Sciences, Josai University
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Kiyota Kengo
Faculty Of Pharmaceutical Sciences Josai University
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Kano Shojiro
Departmentof Clinical Laboratory Tokyo Teishin Hospital
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Hashimoto F
Fac. Of Pharmaceutical Sciences Josai Univ.
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Hashimoto Fumie
Faculty Of Pharmaceutical Sciences Josai University
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Uchino Katsuyoshi
Department Of Hospital Pharmacy Tokyo Postal Service Agency Hospital
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Uchino Katsuyoshi
Departmentof Pharmacy Tokyo Teishin Hospital
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Hayashi Hidenori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Hayashi Hidenori
Faculty Of Bioresources:mie University
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Kobayashi Teruaki
Departmentof Clinical Laboratory Tokyo Teishin Hospital
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Kobayashi Teruaki
Department Of Dermatology Course Of Molecular Medicine Graduate School Of Medicine Osaka University
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Matsushima Teruhiko
Department Of Internal Medicine Tsukuba Memorial Hospital
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