Comparative Study of Protective Effects of Chitin, Chitosan, and N-Acetyl Chitohexaose against Pseudomonas aeruginosa and Listeria monocytogenes Infections in Mice

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概要

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• We conducted a comparative study of the protective effects of chitin, chitosan, and N-acetyl chitohexaose (NACOS-6) against mice infected intravenously or intraperitoneally with Pseudomonas aeruginosa and Listeria monocytogenes. Mice pretreated with chitin, chitosan, and NACOS-6 showed resistance to intraperitoneal infections by both microbes. Only mice pretreated with chitin and chitosan showed resistance to intravenous infections by both microbes. The number, active oxygen generation, and myeloperoxidase activity of peritoneal exudate cells (PEC) in the chitin, chitosan, and NACOS-6-treated mice were greater than those of the untreated mice. Also, these PEC factors from mice pretreated with chitin and chitosan were greater than those from the NACOS-6-treated mice.

• 公益社団法人日本薬学会の論文
• 2003-06-01

著者

• Suzuki Masuko

  Department Of Microbiology Tohoku College Of Pharmacy

• KOBAYASHI Makiko

  Department of Pathology, Tokyo Women's Medical University

• OKAWA Yoshio

  Second Department of Hygienic Chemistry, Tohoku College of Pharmacy

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Josai University

• SUZUKI MASUKO

  Tohoku College of Pharmacy

• SUZUKI Shigeo

  Second Department of Hygienic Chemistry TohokuCollege of Pharmacy

• Suzuki Shigeo

  Department Of Microbiology Tohoku Pharmaceutical University

• Suzuki Masuko

  Department Of Microbiology Tohoku Pharmaceutical University

• Suzuki M

  Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University

• Suzuki M

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Okawa Y

  Department Of Infection And Host Defense Tohoku Pharmaceutical University

• Okawa Y

  Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy

• Kobayashi Makiko

  Department Of Anesthesiology Surugadai Nihon University Hospital

• Suzuki Shigeo

  Second Department Of Hygienic Chemistry Tohoku Pharmaceutical University

• Okawa Yoshio

  Second Dep. Of Hygienic Chemistry Tohoku Pharmaceutical Univ.

• SUZUKI Masuko

  Department of Hygienic Chemistry, Tohoku College of Pharmacy

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