IN VITRO CYTOLYSIS OF MM46 TUMOR CELLS BY MOUSE PHAGOCYTES ACTIVATED BY ACIDIC MANNAN FRACTION OF BAKERS' YEAST

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概要

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• An acidic mannan from bakers' yeast designated as WAM025 was investigated for its augmentative effect on cytolytic activity of phagocytes obtained from the peritoneal cavity of C3H/He strain mice, which had been administered i.p. with this acidic polysaccharide, 150 mg/kg/d, 5 and 10 times. The result of assay for the cytolytic effect of WAM025-activated phagocytes by measuring the amounts of ^3H-uridine of the MM46 tumor cells indicated that a marked lysis of the target cells took place by a 24-h incubation with the activated phagocytes and that a decrease of this effect was observed by the additions of either phagocytic inhibitors or active oxygen scavengers. Because generation of active oxygens from the WAM025-activated phagocytes was also diminished by the additions of the same inhibitors and scavengers, it indicated that active oxygens participated in an important role in the cytolytic effect displayed by the WAM025-activated phagocytes.

• 公益社団法人日本薬学会の論文

著者

• Mikami Takeshi

  Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo

• Mikami T

  Department Of Microbiology Tohoku Pharmceutical University

• Mikami Takeshi

  東北薬科大学 微生物学

• Okawa Yoshio

  Department of Infection and Host Defense, Tohoku Pharmaceutical University

• Suzuki Masuko

  Department Of Microbiology Tohoku College Of Pharmacy

• Mikami Takeshi

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• HASHIMOTO KAZUHIKO

  Department of Surgery, Sakai Municipal Hospital

• SUZUKI MASUKO

  Tohoku College of Pharmacy

• SUZUKI Shigeo

  Second Department of Hygienic Chemistry TohokuCollege of Pharmacy

• Suzuki Shigeo

  Department Of Microbiology Tohoku Pharmaceutical University

• Matsumoto T

  Department Of Microbiology Tohoku Pharmceutical University

• Suzuki Masuko

  Department Of Microbiology Tohoku Pharmaceutical University

• Suzuki M

  Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University

• Suzuki M

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Okawa Y

  Department Of Infection And Host Defense Tohoku Pharmaceutical University

• Okawa Y

  Second Department Of Hygienic Chemistry Tohoku College Of Pharmacy

• Okawa Yoshio

  Department Of Hygienic Chemistry Tohoku Pharmaceutical University:department Of Microbiology Tohoku

• 松本 達二

  東北薬大

• Suzuki Shigeo

  Second Department Of Hygienic Chemistry Tohoku Pharmaceutical University

• Hashimoto Kazuhiko

  Department Of Microbiology:tohoku College Of Pharmacy

• Hashimoto Kazuhiko

  Department Of Chemistry And Materials Technology Kyoto Institute Of Technology

• Hashimoto Kazuhiko

  Department Of Applied Chemistry Faculty Of Engineering Kogakuin University

• MIKAMI Takeshi

  Department of Cardiovasology, Surugadai Nihon University Hospital

• SUZUKI Masuko

  Department of Hygienic Chemistry, Tohoku College of Pharmacy

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