ANTI-TUMOR IMMUNITY AGAINST MAREK'S DISEASE-DERIVED LYMPHOBLASTOID CELL LINE (MSB-1)

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概要

• 論文の詳細を見る

• Cytotoxic effects of peripheral blood lymphocytes (PBL) and immune sera from chickens infected with Marek's disease virus (MDV) or vaccinated with herpesvirus of turkey (HVT) against Marek's disease lymphoblastoid cell line (MSB-1) cells were studied. Cellular immunity was assayed using lymphocytes collected 60 to 180 days postinfection. Lymphocyte cytotoxicity tests revealed that the PBL of MDV infected chickens had cytotoxic effects against MSB-1 but those of HVT-vaccinated chickens did not. In complement-dependent antibody cytotoxicity (CDAC) and antibody-dependent cell-mediated cytotoxicity (ADCC) tests, no cytotoxic activity of sera from MDV- or HVT-infected chickens was demonstrated. However, after the sera of chickens immunized with inactivated MSB-1 cells were extensively absorbed with chicken red blood cells, these sera had cytotoxic effects against MSB-1 cells in CDAC and ADCC tests.

• 北海道大学の論文

著者

• Mikami Takeshi

  Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo

• KODAMA Hiroshi

  Department of Veterinary Immunology, College of Agriculture, University of Osaka Prefecture

• Mikami Takeshi

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• SUGIMOTO Chihiro

  Department of Epizootiology, Faculty of Veterinary Medicine, Hokkaido University

• Sugimoto Chihiro

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• Sugimoto Chihiro

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University

• Kodama Hiroshi

  Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University

• MIKAMI Takeshi

  Department of Cardiovasology, Surugadai Nihon University Hospital

• Kodama Hiroshi

  Department of Chemistry, Faculty of Science, Hokkaido University

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