Cytotoxicity Induced by Recombinant Human Tumor Necrosis Factor-.ALPHA. Dependent on the Types of Its Receptors on Canine Cells.

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概要

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• Based on the recent findings that show how recombinant human tumor necrosis factor (rh-TNF)-α has potent antitumor activity on human cancer patients when it locally administrated, we have tested the cytotoxicity of rh-TNF-α on 3 canine cultured cells: (1) canine kidney carcinoma (CKCa-1), (2) mastocytoma and (3) Mardin Darby canine kidney cells (MDCK). The cell surface expression of TNF-α receptors on these canine cells was also determined with anti-human TNF RI and RII polyclonal antibodies. Our data shows that on CKCa-1 which has TNF RI receptors rh-TNF-α induced cytotoxicity. By contrast, it exhibited no toxicity on canine mastocytoma which has mainly RII receptors. The data also suggest actinomycin D (ACT-D), an anticancer antibiotic, enhanced the cytotoxicity of rh-TNF-α. Combined with ACT-D, rh-TNF-α showed the cytotoxicity on MDCK which possessed both TNF RI and RII receptors. The results indicate that the cytotoxicity of rh-TNF-α depends on the presence of TNF RI receptors on canine tumor cells.

• 公益社団法人 日本獣医学会の論文

著者

• Nomura Koichi

  Department Of Surgery Yatsushiro Health Insurance General Hospital

• Kubo Kihei

  Department Of Advanced Pathobiology Graduate School Of Life & Environmental Sciences Osaka Prefe

• MUKAMOTO Masafumi

  Department of Infectious Disease Control, Division of Veterinary Science, Graduate School of Life an

• Ohashi Fumihito

  Department Of Veterinary Surgery College Of Agriculture Osaka Prefecture University

• Shimada Terumasa

  Veterinary Teaching Hospital College Of Agriculture Osaka Prefecture University

• MUKAMOTO Masafumi

  Department of Veterinary Immunology, College of Agriculture, Osaka Prefecture University

• Sasaki Nobuo

  Department of Biological Science and Technology, Tokyo University of Science

• KUBO Kihei

  Department of Radiology, College of Agriculture, Osaka Prefecture University

• Kodama Hiroshi

  Department of Chemistry, Faculty of Science, Hokkaido University

• KODAMA Hiroshi

  Department of Veterinary Immunology, College of Agriculture, Osaka Prefecture University

• AOKI Mica

  Department of Veterinary Surgery, College of Agriculture, Osaka Prefecture University

• KATAMOTO Hiromu

  Department of Veterinary Surgery, College of Agriculture, Osaka Prefecture University

• SHIMADA Terumasa

  Veterinary Medical Center, Department of Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1–58 Rinku-Oraikita, Izumisano, Osaka 598–8531, Japan

• NOMURA Koichi

  Department of Chemistry, Faculty of Science, Tohoku University

• NOMURA Koichi

  Department of Veterinary Surgery, College of Agriculture, Osaka Prefecture University

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