Comparative Study of Anti-Oncogenic MicroRNA-145 in Canine and Human Malignant Melanoma

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概要

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• MicroRNA (miRNA; miR)-145 is aberrantly expressed in most of human cancers, and plays a significant role in carcinogenesis and cancer progression. In the current study, we focused on how miR-145 plays a role in canine and human malignant melanomas. MiR-145 was significantly down-regulated in canine malignant melanoma tissues and canine melanoma cell lines, as well as human melanoma cell lines tested. The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested, and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC, and human melanoma A2058 and Mewo cells. At the same time, a suppressive tendency of cell migration in canine melanoma KMeC cells, and a significant suppression of cell migration in human melanoma A2058 cells by suppressing FASCIN1 were also found. These findings suggest that miR-145 acts as a tumor suppressor in both canine and human malignant melanomas.

著者

• Nakagawa Takayuki

  Department Of Fisheries Faculty Of Agriculture Kinki University

• Sasaki Nobuo

  Department of Biological Science and Technology, Tokyo University of Science

• SASAKI Nobuo

  Department of Veterinary Surgery, The University of Tokyo

• AKAO Yukihiro

  Comparative Cancer Center, Gifu University

• MORI Takashi

  Department of Applied Physics, Faculty of Engineering, Nagoya University

• NOGUCHI Shunsuke

  The United Graduate School of Veterinary Sciences, Gifu University

• HOSHINO Yuki

  Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University

• YAMADA Nami

  The United Graduate School of Veterinary Sciences, Gifu University

• MARUO Kohji

  Department of Veterinary Clinical Oncology, Gifu University

• HOSHINO Yuki

  Department of Veterinary Clinical Oncology, Gifu University

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