Dermal Cell Damage Induced by Topical Application of Non-Steroidal Anti-Inflammatory Drugs Is Suppressed by Trehalose Co-Lyophilization in Ex Vivo Analysis

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概要

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• Topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) is generally considered safer than oral administration, although the former can occasionally induce cutaneous irritation. We hypothesized that the cutaneous irritation by topical NSAIDs might be suppressed by trehalose, which has protective effects on biological membranes. Using the three-dimensional cultured human skin model, Living Skin Equivalent-high, we found that cutaneous damage due to NSAIDs was reduced by concomitant use of trehalose and that this effect of trehalose was reinforced by co-lyophilization of NSAIDs with trehalose. The anti-inflammatory effect of co-lyophilized NSAIDs with trehalose was comparable to that seen with NSAIDs alone in a rat model. Our results suggest that co-lyophilization of NSAIDs with trehalose might be a novel procedure that can help prevent NSAIDs-induced skin irritation.

著者

• SUZUKI Shigeki

  NEXT21

• Mochizuki Manabu

  Department Of Electronics Faculty Of Engineering Yamanashi University:(present Address)sony

• CHUNG Ung-Il

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

• LIN Lee-Shuan

  Department of Veterinary Surgery, Graduate School of Agriculture and Life Science, The University of Tokyo

• Sasaki Nobuo

  Department of Biological Science and Technology, Tokyo University of Science

• FUJISAWA Ayano

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 2–11–16 Yayoi, Bunkyo-ku, Tokyo 113–8656, Japan

• IWANAGA Shintaroh

  Institute of Industrial Science, The University of Tokyo, 4–6–1 Komaba, Meguro-ku, Tokyo 153–8904, Japan

• KAYASUGA-KARIYA Yuko

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 2–11–16 Yayoi, Bunkyo-ku, Tokyo 113–8656, Japan

• SHIMOHATA Nobuyuki

  Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 2–11–16 Yayoi, Bunkyo-ku, Tokyo 113–8656, Japan

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