Facilitative Effect of a Glutamate Transporter Inhibitor (2S,3S)-3-{3-[4-(Trifluoromethyl)benzoylamino]benzyloxy} aspartate on the Expression of Methamphetamine-Induced Behavioral Sensitization in Rats

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概要

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• We examined the effects of a potent glutamate transporter inhibitor, (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate (TFB-TBOA), on the expression of methamphetamine-induced behavioral sensitization in rats. Rats were intraperitoneally treated with 2 mg/kg methamphetamine for 5 days and then challenged with 1 mg/kg methamphetamine. Intracerebroventricular administration of TFB-TBOA (0.1 nmol) 10 min before the challenge significantly facilitated the expression of behavioral sensitization. On the other hand, it had no effect on the locomotor activation elicited by the challenge with methamphetamine in repeated-saline-treated (non-sensitized) rats. These results suggest that central glutamate transporters may play an inhibitory role in the expression of behavioral sensitization to methamphetamine.

• 社団法人 日本薬理学会の論文
• 2005-12-20

著者

• KANEKO Shuji

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• NAKAGAWA Takayuki

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Nakagawa Takayuki

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Nakagawa Takayuki

  Department Of Fisheries Faculty Of Agriculture Kinki University

• Kaneko Shuji

  Dep. Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• SUZUKI Yuichi

  Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University

• Nakagawa Takayuki

  Dep. Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn

• FUJIO Mayumi

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• SATOH Masamichi

  Nara Institute of Science and Technology

• Kaneko Shuji

  Department Of Applied Biological Chemistry Graduate School Of Agricultural Science Kobe University

• Satoh Masamichi

  Yasuda Women's Univ. Jpn

• Fujio Mayumi

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Satoh Masamichi

  Department Of Hygiene And Preventive Medicine Faculty Of Medicine Saitama Medical School

• Suzuki Yuichi

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Suzuki Yuichi

  Department Of Bioscience And Chemistry Faculty Of Agriculture Hokkaido University

• Satoh Masamichi

  Nara Inst. Of Sci. & Tech.

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