A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide

スポンサーリンク

概要

• 論文の詳細を見る

• A brief exposure to hydrogen peroxide (H2O2) induces severe deterioration of primary cultured neurons in vitro. We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR). In cultured cerebral cortical neurons from fetal rat, TRPM2 proteins were detected at cell bodies and neurite extensions. Application of H2O2 to the cultured neurons elicited an increase in intracellular Ca2+ concentration ([Ca2+]i) caused by Ca2+ influx and the Ca2+-dependent neuronal death in a similar concentration range. Molecular cloning of TRPM2 cDNA from rat brain revealed several differences in amino acid sequences within the Nudix box region as compared with those of human and mouse TRPM2. ADPR-induced current responses, H2O2-induced Ca2+ influx, and H2O2-induced cell death were induced in human embryonic kidney cells heterologously expressing rat TRPM2. Treatment of cultured neurons with small interfering RNA against rat TRPM2, which efficiently suppressed immunoreactive TRPM2 content and the H2O2-induced Ca2+ influx, significantly inhibited H2O2-induced neuronal death. These results suggest that TRPM2 plays a pivotal role in H2O2-induced neuronal death as redox-sensitive Ca2+-permeable channels expressed in neurons.

• 社団法人 日本薬理学会の論文
• 2006-05-20

著者

• Katsuki Hiroshi

  Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto

• Kume Toshiaki

  京都大学 薬学研究科生体機能解析学

• Kume Toshiaki

  京都大学 薬学研究科薬品作用解析学分野

• Kume Toshiaki

  京都大学 薬学研究科薬品作用解析学

• Kume Toshiaki

  同志社女子大学 医療薬学科薬理学

• Kume Toshiaki

  Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology

• Takada-takatori Yuki

  京都大学 薬学研究科薬品作用解析学

• Akaike A

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Akaike Akinori

  京都大学 薬学研究科生体機能解析学

• Akaike Akinori

  京都薬科大学 病態生理

• Akaike Akinori

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Kume Toshiaki

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University

• KANEKO Shuji

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Hara Yuji

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Hara Yuji

  Center For Integrative Bioscience Okazaki National Research Institutes

• MORI Yasuo

  Laboratory of Molecular Biology, Department of Synthetic and Biological Chemistry, Graduate School o

• Honda Y

  Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University

• Akaike Akinori

  Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology

• KAWAKAMI Seiko

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• HARA Yuji

  Laboratory of Molecular Biology, Graduate School of Engineering, Kyoto University

• WAKAMORI Minoru

  Laboratory of Molecular Biology, Graduate School of Engineering, Kyoto University

• ITOH Etsuko

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• MINAMI Toshiyuki

  Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• TAKADA Yuki

  Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Wakamori Minoru

  Laboratory Of Molecular Biology Graduate School Of Engineering Kyoto University

• Kaneko Satoshi

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Itoh Etsuko

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Takada Yuki

  Department Of Applied Chemistry And Bio Engineer Ing Graduate School Of Engineering Osaka City Unive

• Kawakami Seiko

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Kaneko Shuji

  Department Of Applied Biological Chemistry Graduate School Of Agricultural Science Kobe University

• Tochikawa Yoshinaga

  Institute Of Research And Development Fujimoto Pharmaceutical Corporation

• Katsuki Hiroshi

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Takada-takatori Yuki

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Doshisha Women's College

• Akaike Akinori

  Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn

• Katsuki Hiroshi

  Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U

• Minami Toshiyuki

  Department Of Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Mori Yasuo

  Laboratory Of Molecular Biology Graduate School Of Engineering Kyoto University

• Mori Yasuo

  Laboratory Of Food Chemistry Faculty Of Fisheries Kagoshima University

• Kume T

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Akaike Akinori

  Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Hara Yuji

  Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University

関連論文

• Identification of a Novel Planarian G-Protein-Coupled Receptor That Responds to Serotonin in Xenopus laevis Oocytes
• Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
• Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
• Neuropsychotoxicity of Abused Drugs : Molecular and Neural Mechanisms of Neuropsychotoxicity Induced by Methamphetamine, 3,4-Methylenedioxymethamphetamine (Ecstasy), and 5-Methoxy-N,N-diisopropyltryptamine (Foxy)
• Neuropsychotoxicity of Abused Drugs : Clinical and Basic Research and Drug Development : Preface
• Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
• Extracellular-Added ADP-Ribose Increases Intracellular Free Ca^ Concentration Through Ca^ Release From Stores, but Not Through TRPM2-Mediated Ca^ Entry, in Rat β-Cell Line RIN-5F
• Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
• Excitotoxicity-Associated p53 Expression in Adult Rat Retina Is Mediated by Calpain Activity but Not by Cl^- Influx
• Roles of Nicotinic Receptors in Acetylcholinesterase Inhibitor-Induced Neuroprotection and Nicotinic Receptor Up-Regulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
• Serofendic Acid Promotes Stellation Induced by cAMP and cGMP Analogs in Cultured Cortical Astrocytes
• Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion
• Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor-κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors
• PJ-104 Serofendic Acid, a Novel Substance Extracted from Fetal Calf Serum, Protects against Oxidative Stress in Neonatal Rat Cardiac Myocytes(Myocardial ischemia-reperfusion, basic/clinical-5 (IHD) PJ18,Poster Session (Japanese),The 70th Anniversary Annua
• Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
• Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells
• Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
• The Parkinsonian Models : Invertebrates to Mammals
• Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
• Foreword(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
• Co-culture With the Striatum Attenuates N-Methyl-D-aspartate Cytotoxicity in Dopaminergic Neurons of Rat Mesencephalic Slice Cultures
• Bifemelane Protects Cultured Cortical Neurons Against N-Methyl-D-aspartate Receptor-Mediated Glutamate Cytotoxicity
• Protective Effect of MKC-231, a Novel High Affinity Choline Uptake Enhancer, on Glutamate Cytotoxicity in Cultured Cortical Neurons
• Suppressive effect of zinc ion on iNOS expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocytes
• Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
• EFFECTS OF OPIOID PEPTIDES ON NEURONAL ACTIVITIES OF THE CNS : STUDIES USING MICROELECTROPHORETIC METHOD
• Neuroprotective action of donepezil mediated by neuronal nicotinic receptors
• A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
• Collocational Analysis of Life Science English (1) : Lists of common collocates of possibility, probability, implication, involvement, absence, presence, evidence
• Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
• Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo
• Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
• Endogenous Factors Regulating Neuronal Death Induced by Radical Stress(Mitochondria and Neuroprotection)
• Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
• Ether Extract of Fetal Cakf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity
• Saccharomyces cerevisiae Mutant Displaying β-Glucans on Cell Surface(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
• Basic and Clinical Aspects of Non-neuronal Acetylcholine : Expression of an Independent, Non-neuronal Cholinergic System in Lymphocytes and Its Clinical Significance in Immunotherapy
• Effects of R-(-)-BPAP on the Expressions of Neurotrophins and Their Receptors in Mesencephalic Slices(Pharmacology)
• Electron Wave Transfer in Coupled Quantum Wires and Its Control by Externally Applied Electric Field
• Effect of Specific Binding of High Density Lipoprotein to Eel Hepatocytes on Their Secretion of Lipoprotein
• Furosemide : Sensitive Calcium Rise Induced by GABA_A : Receptor Stimulation in Cultures of Embryonic Rat Striatal Neurons
• Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5′-Triphosphate in the Rat
• Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
• The Involvement of Aldose Reductase in Alterations to Neurotrophin Receptors and Neuronal Cytoskeletal Protein mRNA Levels in the Dorsal Root Ganglion of Streptozotocin-Induced Diabetic Rats
• Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
• Facilitative Effect of a Glutamate Transporter Inhibitor (2S,3S)-3-{3-[4-(Trifluoromethyl)benzoylamino]benzyloxy} aspartate on the Expression of Methamphetamine-Induced Behavioral Sensitization in Rats
• Involvement of TRPM7 in Cell Growth as a Spontaneously Activated Ca^ Entry Pathway in Human Retinoblastoma Cells
• Current Perspective : Dissecting Receptor-Mediated Ca^ Influx Pathways : TRP Channels and Their Native Counterparts
• Receptor-Mediated Modulation of Voltage-Dependent Ca^ Channels via Heterotrimeric G-proteins in Neurons
• Inhibitory Effects of Bifemelane on Brain Ca^ Channel Subtypes Expressed in Xenopus Oocytes
• Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice
• Involvement of M_2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices
• Purification and Characterization of an Extracellular Laccase from Phlebia radiata Strain BP-11-2 That Decolorizes Fungal Melanin
• Purification and Characterization of an Extracellular Laccase from Phlebia radiata Strain BP-11-2 That Decolorizes Fungal Melanin
• Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
• Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
• Glycyrrhizin Attenuates Mucus Production by Inhibition of MUC5AC mRNA Expression In Vivo and In Vitro
• Glycyrrhizin Inhibits IL-8 Production and NF-κB Activity in Lung Epithelial Cells, But Not Through Glucocorticoid Receptors
• Effects of vitamin B_6 and its related compounds on survival of cultured brain neurons
• The Effects of Thiamine and Oxythiamine on the Survival of Cultured Brain Neurons
• YM-14673,a New Thyrotropin-Releasing Hormone Analog, Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
• Indeloxazine Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
• Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures
• Differential Contribution of Spinal Mitogen-Activated Protein Kinases to the Phase of Long-Lasting Allodynia Evoked by Intrathecal Administration of ATP in Rats(Pharmacology)
• 3-Hydroxykynurenine Toxicity on the Rat Striatum In Vivo
• Spinal Astrocytes as Therapeutic Targets for Pathological Pain
• BRADYKININ-INDUCED FLEXOR REFLEX OF RABBIT HINDLIMB FOR COMPARING ANALGESICS
• EFFECTS OF INDOMETHACIN AND THE OTHER ANTI-INFLAMMATORY AGENTS ON ACTIVATION OF DORSAL HORN CELL IN THE SPINAL CORD INDUCED BY INTRA-ARTERIAL INJECTION OF BRADYKININ
• Effects of coculture with the septum on the expression of long-term potentiation in organotypic hippocampal slice cultures
• Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
• Na^+/Ca^ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
• Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5'-Triphosphate in the Rat
• Glutathione Biosynthesis via Activation of the Nuclear Factor E2-Related Factor 2 (Nrf2)-Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
• Exploring Neuroprotective Drug Therapies for Intracerebral Hemorrhage
• Spinal Astrocytes as Therapeutic Targets for Pathological Pain
• Two cases of leptomeningeal metastases from lung adenocarcinoma which progressed during gefitinib therapy but responded to erlotinib
• Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease
• Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
• Glucocorticoids Decrease Astrocyte Numbers by Reducing Glucocorticoid Receptor Expression In Vitro and In Vivo
• In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
• Glucocorticoids Decrease Astrocyte Numbers by Reducing Glucocorticoid Receptor Expression In Vitro and In Vivo
• In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
• Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
• Involvement of TRPM7 in Cell Growth as a Spontaneously Activated Ca2+ Entry Pathway in Human Retinoblastoma Cells
• A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide
• Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation.
• Effects of Protein Kinase C on the Muscarinic Excitation of Rat Adrenal Chromaffin Cells.
• Acetals of N,N-Dimethylformamides : Ambiphilic Behavior in Converting Carbon Dioxide to Dialkyl Carbonates
• A Novel Mouse Model of Chronic Inflammatory and Overactive Bladder by a Single Intravesical Injection of Hydrogen Peroxide
• Physical and functional interaction of the active zone protein CAST/ERC2 and the β-subunit of the voltage-dependent Ca^ channel
• Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice

もっと見る 閉じる

スポンサーリンク