Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
スポンサーリンク
概要
- 論文の詳細を見る
Previously we demonstrated that nicotinic acetylcholine receptor stimulation protects neurons against beta-amyloid (Aβ)-induced cytotoxicity. In the present study, the effects of nicotinic receptor agonists on the β-sheet formation were investigated using a thioflavin T (ThT)-based fluorescence assay. Nicotine, cytisine (an α4β2 agonist), and 3-(2, 4)-dimethoxybenzylidene anabaseine (DMXB, an α7 agonist) did not reduce fluorescence intensity when these agents were added to the β-sheet-formed Aβ. Simultaneous incubation of Aβ with nicotinic agonists also did not cause a reduction in fluorescence intensity. This data suggests that nicotinic receptor agonists do not influence the formation of the β-sheet structure.
- 社団法人 日本薬理学会の論文
- 1999-03-01
著者
-
Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
-
Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
-
Shimohama Shun
Department Of Neurology Graduate School Of Medicine Kyoto University
-
Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
-
Kihara Takeshi
Department Of Neurology Graduate School Of Medicine Kyoto University
-
Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
-
Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
関連論文
- Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K2 in Corticosteroid-Treated Patients: A Pilot Study
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
- Excitotoxicity-Associated p53 Expression in Adult Rat Retina Is Mediated by Calpain Activity but Not by Cl^- Influx
- Roles of Nicotinic Receptors in Acetylcholinesterase Inhibitor-Induced Neuroprotection and Nicotinic Receptor Up-Regulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Serofendic Acid Promotes Stellation Induced by cAMP and cGMP Analogs in Cultured Cortical Astrocytes
- PJ-104 Serofendic Acid, a Novel Substance Extracted from Fetal Calf Serum, Protects against Oxidative Stress in Neonatal Rat Cardiac Myocytes(Myocardial ischemia-reperfusion, basic/clinical-5 (IHD) PJ18,Poster Session (Japanese),The 70th Anniversary Annua
- Proteasome Inhibitors Protect Against Degeneration of Nigral Dopaminergic Neurons in Hemiparkinsonian Rats
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-△^ Prostaglandin J_2-Sensitive Microglial Activation
- Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells
- Dual effect of serotonin on formalin-induced nociception in the rat spinal cord
- The Parkinsonian Models : Invertebrates to Mammals
- Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
- Foreword(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Co-culture With the Striatum Attenuates N-Methyl-D-aspartate Cytotoxicity in Dopaminergic Neurons of Rat Mesencephalic Slice Cultures
- Bifemelane Protects Cultured Cortical Neurons Against N-Methyl-D-aspartate Receptor-Mediated Glutamate Cytotoxicity
- Protective Effect of MKC-231, a Novel High Affinity Choline Uptake Enhancer, on Glutamate Cytotoxicity in Cultured Cortical Neurons
- Suppressive effect of zinc ion on iNOS expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocytes
- Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
- EFFECTS OF OPIOID PEPTIDES ON NEURONAL ACTIVITIES OF THE CNS : STUDIES USING MICROELECTROPHORETIC METHOD
- Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model
- Neuroprotective action of donepezil mediated by neuronal nicotinic receptors
- A Critical Role of TRPM2 in Neuronal Cell Death by Hydrogen Peroxide
- Donepezil Potentiates Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells
- Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo
- Mechanisms of oxygen glucose deprivation-induced glutamate release from cerebrocortical slice cultures
- Endogenous Factors Regulating Neuronal Death Induced by Radical Stress(Mitochondria and Neuroprotection)
- Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor
- Ether Extract of Fetal Cakf Serum Protects Cultured Rat Cortical Neurons against Glutamate Cytotoxicity
- Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus
- Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells
- Effects of R-(-)-BPAP on the Expressions of Neurotrophins and Their Receptors in Mesencephalic Slices(Pharmacology)
- Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia
- Involvement of Wiskott-Albrich Syndrome Protein Family Verprolin- Homologous Protein (WAVEAa9 and Rac1 in the Phagocytosis of Amyloid-β(1-42) in Rat Microglia
- Apoptotic Cell Death in Neurons and Glial Cells : Implications for Alzheimer's Disease
- Possible Involvement of Rapamycin-Sensitive Pathway in Bcl-2 Expression in Human Neuroblastoma SH-SY5Y Cells
- Hypersomnia Caused by Isolated Angiitis of the CNS
- Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
- Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
- Transient Oculomotor Palsy Correlated with Nerve Enhancement on MRI in Chronic Inflammatory Demyelinating Polyneuropathy
- Assessment of Protein Kinase C mRNA Levels in Alzheimer's Disease Brains
- Analysis of prognostic factors related to primary superficial bladder cancer tumor recurrence in prophylactic intravesical epirubicin therapy
- Receptor-Mediated Modulation of Voltage-Dependent Ca^ Channels via Heterotrimeric G-proteins in Neurons
- Inhibitory Effects of Bifemelane on Brain Ca^ Channel Subtypes Expressed in Xenopus Oocytes
- Inhibition by [Arg8]-Vasopressin of Long Term Potentiation in Guinea Pig Hippocampal Slice
- Involvement of M_2 receptor in an enhancement of long-term potentiation by carbachol in Schaffer collateral-CA1 synapses of hippocampal slices
- Abundance of Low Molecular Weight Phosphotyrosine Protein Phosphatase in the Nerve-Ending Fraction in the Brain
- Alterations of Phospholipase C Isozymes in Rat Cerebral Cortex through Hyperoxia
- Mechanisms of Chronic Nicotine Treatment-Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons
- The Hydroxyl Radical Formation System in Polymorphonuclear Leukocytes
- Participation of Cytosolic Protein Phosphatase in Regulation of NADPH Oxidase in Polymorphonuclear Leukocytes
- Zinc-Ion-Dependent Acid Phosphatase Exhibits Magnesium-Ion-Dependent myo-Inositol-1-phosphatase Activity
- Characterization of High- and Low-Molecular Weight Zinc-Dependent Acid Phosphatases in Bovine Liver
- Clinical Outcome of Patients with SREDA (Subclinical Rhythmic EEG Discharge of Adults)
- BRADYKININ-INDUCED FLEXOR REFLEX OF RABBIT HINDLIMB FOR COMPARING ANALGESICS
- EFFECTS OF INDOMETHACIN AND THE OTHER ANTI-INFLAMMATORY AGENTS ON ACTIVATION OF DORSAL HORN CELL IN THE SPINAL CORD INDUCED BY INTRA-ARTERIAL INJECTION OF BRADYKININ
- Nicotinic Receptor-Mediated Neuroprotection in Neurodegenerative Disease Models(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures
- Na^+/Ca^ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
- Glutathione Biosynthesis via Activation of the Nuclear Factor E2-Related Factor 2 (Nrf2)-Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
- Glucocorticoids Decrease Astrocyte Numbers by Reducing Glucocorticoid Receptor Expression In Vitro and In Vivo
- Thyrotoxic Myopathy Mimicking Myasthenic Syndrome Associated with Thymic Hyperplasia
- In Vivo Brain Oxidative Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
- Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice
- Gluten Sensitivity in Japanese Patients with Adultonset Cerebellar Ataxia
- Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation.
- Effects of Protein Kinase C on the Muscarinic Excitation of Rat Adrenal Chromaffin Cells.
- Reassessment of (3H)glutamate binding to human brain membrane preparations.
- Protective Effect of Luteolin on an Oxidative-Stress Model Induced by Microinjection of Sodium Nitroprusside in Mice