Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells
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概要
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To elucidate the role of Na+/Ca2+ exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3′,4′-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX inhibitors inhibited the neurite outgrowth caused by dibutylyl cAMP, which rapidly reorganizes the cytoskeleton. KB-R7943 inhibited the neurite outgrowth caused by Y-27632, an inhibitor of Rho kinase (ROCK) that regulates actin. However, NCX inhibitors did not inhibit NGF-induced phosphorylation of extracellular signal-regulated kinase. These results suggest that NCX inhibitor affects downstream of the Rho–ROCK signal transduction pathways in neurite outgrowth.
著者
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Izumi Yasuhiko
京都大学 薬学研究科薬品作用解析学分野
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Izumi Yasuhiko
京都大学 薬学研究科薬品作用解析学
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Izumi Yasuhiko
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Kume Toshiaki
京都大学 薬学研究科生体機能解析学
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Kume Toshiaki
京都大学 薬学研究科薬品作用解析学分野
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Kume Toshiaki
京都大学 薬学研究科薬品作用解析学
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Kume Toshiaki
同志社女子大学 医療薬学科薬理学
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Kume Toshiaki
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Kume Toshiaki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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ODA Toru
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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Ishihara Kumatoshi
Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International Univers
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Sugmimoto Hachiro
World-Leading Drug Discovery Research Center, Graduate School of Pharmaceutical Sciences, Kyoto Univ
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Ishihara Kumatoshi
Laboratory Of Neuropharmacology Faculty Of Pharmaceutical Sciences Hiroshima International Universit
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Kume T
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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