Effects of R-(-)-BPAP on the Expressions of Neurotrophins and Their Receptors in Mesencephalic Slices(Pharmacology)
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概要
- 論文の詳細を見る
R-(-)-1-(Benzofuran-2-yl)-2-propylaminopentane [R-(-)-BPAP] enhances electric field stimulation-induced release of catecholamine from isolated brain stem and ameliorates motor deficits in rats. We evaluated the effects of R-(-)-BPAP on the expression of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), and their receptors, trkB and p75^<NTR> in rat mesencephalic slice cultures. Levels of mRNA and protein were measured at 48h after R-(-)-BPAP treatment by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. R-(-)-BPAP significantly increased the mRNA and protein levels of BDNF, without affecting the level of NT-3 mRNA. In addition, R-(-)-BPAP significantly increased the mRNA level of trkB, but not that of p75^<NTR>. These effects of R-(-)-BPAP may result in enhanced BDNF/trkB signaling, and could thus underlie the potential neurotrophic and antidepressant actions of this drug.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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Katsuki Hiroshi
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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Akaike A
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
京都大学 薬学研究科生体機能解析学
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Akaike Akinori
京都薬科大学 病態生理
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Akaike Akinori
Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University
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Akaike Akinori
Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology
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HAYASHI Kyozo
Gifu College of Medical Technology
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HIRAMI Chieko
Research Institute, Fujimoto Pharmaceutical Corporation
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TAKAHATA Kazue
Research Institute, Fujimoto Pharmaceutical Corporation
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SHIMAZU Seiichiro
Research Institute, Fujimoto Pharmaceutical Corporation
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YONEDA Fumio
Research Institute, Fujimoto Pharmaceutical Corporation
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Yoneda Fumio
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
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Hirami Chieko
Research Institute Fujimoto Pharmaceutical Corporation
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Takahata Kazue
Institute Of Research And Development Fujimoto Pharmaceutical Corporation
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Katsuki Hiroshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Akaike Akinori
Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn
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Katsuki Hiroshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Hayashi Kyozo
Gifu Pharmaceutical University
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Shimazu Seiichiro
Research Institute Fujimoto Pharmaceutical Corporation
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Akaike Akinori
Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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