The Parkinsonian Models : Invertebrates to Mammals

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概要

• 論文の詳細を見る

• In contrast to Alzheimer’s disease, effective therapeutic options are available for Parkinson’s disease. Therapy of dopamine replacement such as levodopa improves the symptoms of this disease, but does not inhibit neurodegeneration in the substantia nigra. Numerous studies have suggested that endogenous and environmental neurotoxins, and oxidative stress may participate in this disease, but the detailed mechanisms are still unclear. Recent genetic studies in familial Parkinson’s disease and parkinsonism show several gene mutations. This new information regarding pathogenesis offers novel prospects for therapy. To develop novel neuroprotective drugs, it is necessary to have a model for each type of parkinsonism. This review summarizes current findings regarding parkinsonian models in vertebrates and invertebrates and discusses their value.

• 社団法人 日本薬理学会の論文
• 2000-11-01

著者

• Taniguchi Takashi

  Department of Geophysics, Faculty of Science, Hokkaido University

• Taniguchi T

  Department Of Neurobiology Kyoto Pharmaceutical University

• Akaike A

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Akaike Akinori

  京都大学 薬学研究科生体機能解析学

• Akaike A

  Dep. Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto Univ. Jpn

• Akaike Akinori

  京都薬科大学 病態生理

• Taniguchi Takashi

  京都薬科大学 病態生理学

• Akaike Akinori

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Kyoto University

• Shimohama Shun

  Department of Neurology, Sapporo Medical University School of Medicine

• KITAMURA Yoshihisa

  Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

• Shimohama S

  Kyoto Univ. Kyoto Jpn

• Shimohama Shun

  Department Of Neurology Faculty Of Medicine Kyoto University

• Akaike Akinori

  Department Of Pharmaceutical Science Kyoto University Graduate School Of Pharmacology

• Takenawa Tadaomi

  Division Of Biochemistry Institute Of Medical Science University Of Tokyo

• Kitamura Yoshihisa

  Department Of Neurobiology Kyoto Pharmaceutical University

• Kitamura Yoshihisa

  Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive

• Kitamura Y

  Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn

• Taira Takahiro

  Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co

• Takano T

  Dep. Of Neurobiology Kyoto Pharmaceutical Univ.

• Taniguchi Takashi

  Department Of Geophysics Faculty Of Science Hokkaido University

• Taniguchi Takashi

  Department Of Dermatology Faculty Of Medicine University Of Tokyo

• TANIGUCHI Takashi

  Department of Computational Science and Engineering, Nagoya University

• Kitamura Yoshihisa

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan

• Taniguchi Takashi

  Department of Biology, Kyoto Pharmaceutical University

• Akaike Akinori

  Department of Neuropharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• KITAMURA Yoshihisa

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University

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