Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone-Treated Rats
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概要
- 論文の詳細を見る
In the present study, we investigated the effect of adrenocorticotropic hormone (ACTH) on the immobilization of rats in the forced swim test after the administration of selegiline, a selective and irreversible monoamine oxidase (MAO)-B inhibitor. Single and repeated administration of selegiline significantly decreased the duration of immobility in normal rats. When selegiline was administered for 15 days, we observed a significant decrease in immobility in rats treated with ACTH for 14 days. The immobility-decreasing effect of selegiline was blocked by nafadotride, a selective dopamine D3–receptor antagonist in normal and ACTH-treated rats. Selegiline may be useful in an animal model of depressive conditions resistant to tricyclic antidepressant treatment via the dopamine D3 receptor.
- 社団法人 日本薬理学会の論文
- 2008-04-20
著者
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Sendo Toshiaki
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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Sagara Hidenori
Department Of Hospital Pharmacy Okayama University Medical School
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Sagara Hidenori
岡山大学 大学院医歯薬学総合研究科医薬管理学
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Sagara Hidenori
松山大学 医薬情報解析学
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Sagara Hidenori
岡山大学医学部附属病院 薬剤部
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Sagara Hidenori
岡山大学病院 薬剤部
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Sagara Hidenori
岡山大学 臨床薬剤学分野
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Gomita Yutaka
Dep. Of Hospital Pharmacy Okayama Univ. Medical School Jpn
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Gomita Yutaka
岡山大学 医歯薬学総合研究科医薬管理学
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Gomita Y
Okayama Univ. Medical School Okayama Jpn
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Gomita Y
Shujitsu Univ. School Of Pharmacy Okayama Jpn
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Suemaru Katsuya
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Sendo T
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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Gomita Yutaka
Department Of Hospital Pharmacy
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Gomita Yutaka
吉備国際大学 保健科学部作業療法学科
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Gomita Yutaka
科研製薬総合研究所
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SHIBATA Kazuhiko
Department of Pharmaceutical Information Sciences, Matsuyama University
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KITAGAWA Kouhei
Department of Hospital Pharmacy, Okayama University Medical School
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KIMOTO Shizue
Department of Hospital Pharmacy, Okayama University Medical School
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Gomita Y
Daiichi Coll. Pharmaceutical Sciences Fukuoka Jpn
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Shibata Kazuhiko
Department Of Hospital Pharmacy Okayama University Medical School
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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Kitagawa Kouhei
Department Of Pharmaceutical Care And Health Sciences Graduate School Of Medicine Dentistry And Phar
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kawasaki Yoichi
Department Of Pharmacy Okayama University Hospital
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Kitamura Yoshihisa
Department Of Pharmaceutical Care And Health Science Graduate School Of Medicine Dentistry And Pharm
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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