Effect of Adrenomedullin on Adrenergic Vasoconstriction in Mesenteric Resistance Arteries of the Rat
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概要
- 論文の詳細を見る
Adrenomedullin (AM) is a hypotensive peptide that belongs to a family of peptides structurally related to calcitonin gene-related peptide (CGRP). The present study examined the effect of AM on adrenergic nerve-mediated vasoconstriction in rat perfused mesenteric vascular beds without endothelium. Perfusion of AM at 0.1 nM but not 10 nM increased vasoconstrictor responses to periarterial nerve stimulation (PNS) (1 – 4 Hz), while AM at 10 nM significantly attenuated vasoconstriction induced by bolus injection of norepinephrine (NE). In preparations treated with capsaicin (a CGRP depletor), pressor responses to both PNS and NE injection were markedly attenuated by AM. Perfusion of CGRP(8 – 37) (a CGRP-receptor antagonist) significantly potentiated the PNS- but not the NE-induced vasoconstriction. Combined perfusion of CGRP(8 – 37) and AM had no effect on the PNS-induced response and antagonized the inhibitory effect of AM on the NE-induced response. AM(22 – 52) (an AM-receptor antagonist) did not influence the effect of AM. These findings suggest that AM facilitates adrenergic vasoconstriction by inhibiting neurotransmission of CGRP-containing nerves, which counteract adrenergic nerve-mediated vasoconstriction.
- 社団法人 日本薬理学会の論文
- 2005-11-20
著者
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Hobara Narumi
Department Of Life Science Okayama University Of Science
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Kawasaki Hiromu
Dep. Of Clinical Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okay
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Kawasaki Hiromu
岡山大学 医歯薬学総合研究科臨床薬学
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HATANAKA Yukako
Department of Clinical and Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharma
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Hatanaka Yukako
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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TAKAYAMA Fusako
Department of Pharmacology, Oita Medical University
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Hobara Narumi
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Science Graduate School Of B
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AKIYAMA Shinji
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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JIN Honghua
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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KOSUGI Keiji
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Jin Honghua
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Kosugi Keiji
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Akiyama Shinji
Department Of Clinical Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmaceutic
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Takayama Fusako
Department Of Pharmacology Oita Medical University
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Takayama Fusako
Department Of Pharmacology
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Hashikawa Hobara
Department Of Life Science Okayama University Of Science
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Hatanaka Yukako
Dep. Of Clinical Pharmaceutical Sci. Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama ...
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Takayama Fusako
Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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