Effect of Long-Term Fluvoxamine Treatment on Endogenous Serotonin Uptake Inhibitor-Like Substance in Monkey Cerebrospinal Fluid
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概要
- 論文の詳細を見る
We found that substances present in monkey cerebrospinal fluid (CSF) could inhibit [<SUP>3</SUP>H]-paroxetine binding in monkey brain preparations. The molecular weight of one of these inhibitory substances was approximately 2000, which is in agreement with earlier studies using human CSF. We also found that the inhibitory effect of the substances present in monkey CSF on [<SUP>3</SUP>H]-paroxetine binding decreased after 8 weeks of chronic fluvoxamine (5 mg/kg day, p.o.) treatment. These results suggest that the ability of a drug to decrease the activity of endogenous 5-HT uptake modulators may related to its antidepressive effects.
- 社団法人 日本薬理学会の論文
- 1995-02-01
著者
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Wada Yuji
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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YAMANAKA YASUMITSU
Medical College of Oita
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Yamanaka Yasumitu
Department Of Pharmacology Oita Medical University
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Yamanaka Yasumitsu
Depts. Of Pharmacology Medical College Of Oita
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Yamanaka Yasumitsu
Department Of Pharmacology Oita Medical University
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Wada Yuji
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Egashira Toru
Dept. Pharmacol. Med. College Of Oita
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Yamanaka Y
Department Of Pharmacology Oita Medical University
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TAKAYAMA Fusako
Department of Pharmacology, Oita Medical University
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GOTO Shinichiro
Department of Pharmacology, Oita Medical University
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Egashira T
Oita Medical Univ. Oita Jpn
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Takayama Fusako
Department Of Pharmacology Oita Medical University
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Takayama Fusako
Department Of Pharmacology
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Wada Yuji
Department Of Pharmacology Oita Medical University
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Goto Shinichiro
Department Of Pharmacology Oita Medical University
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Egashira Toru
Dept. Of Pharmacol. Oita Med. U.
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Takayama Fusako
Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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