Changes in MAO activities in several organs of rats after administration of l-thyroxine.
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概要
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Male rats were given daily injections of 200 μg/kg <I>I</I>-thyroxine, s.c., for a period of 10 days. Monoamine oxidase (MAO) activities in the heart, lung and liver mitochondria decreased rapidly to about 50% those of the control rats with 5-HT and β-phenylethylamine (β-PEA) as substrates on the first day. After that, heart MAO activity increased gradually and exceeded the control value after 10 days with 5-HT as the substrate. The level of liver MAO activity was maintained at about 50-70% during the same period of administration with 5-HT as the substrate. The thyroxine treated rats showed no marked change in brain MAO activity. In vitro, <I>I</I>-thyroxine and its metabolites had no discriminative actions on MAO activities in these organs of rats. The heart, lung and liver MAO have unaltered K<SUB>m</SUB> values for 5-HT and β-PEA, but decreases in the V<SUB>max</SUB> for both substrates were observed between the control and <I>I</I>-thyroxine-treated rats. Addition of the brain, heart and liver cytosol fractions from <I>I</I>-thyroxine treated rats caused MAO activities of heart mitochondria to decrease with 5-HT as a substrate and caused them to increase with β-PEA as a substrate. MAO activities in liver also were inhibited by adding all the cytosols when β-PEA was the substrate, but on the contrary, lung MAO activities were increased when 5-HT was the substrate. These results indicate the possible presence of multiple modulators of MAO in the cytosol fractions of <I>I</I>-thyroxine treated rats.
- 公益社団法人 日本薬理学会の論文
著者
-
Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Yamanaka Yasumitsu
Department Of Pharmacology Oita Medical University
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