Antioxidant and Hepatoprotective Actions of the Medicinal Herb Artemisia campestris from the Okinawa Islands
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概要
- 論文の詳細を見る
The antioxidant action of Artemisia camprestris was examined in vitro and in vivo. A water extract of A. campestris showed a strong scavenging action of 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals. When the extract was given intraperitoneally to mice prior to carbon tetrachloride (CCl_4) treatment, CCl_4-induced liver toxicity, as seen by an elevation of serum aspartate aminotransferase and alanine aminotransferase activities, was significantly reduced. Depression of the elevation of serum enzyme levels after CCl_4-treatment was also observed by oral administration of the extract. In that case, CCl_4-derived lipid peroxidation in the liver was decreased by the extrac treatment. These results suggest that the extract of A. comprestris scavenges radicals formed by CCl_4 treatment resulting in protection against CCl_4-induced liver toxicity.
- 公益社団法人日本薬学会の論文
- 2000-03-01
著者
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Aniya Yoko
Laboratory of Molecular Genetics and Pharmacology, School of Health Sciences, Faculty of Medicine, U
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Aniya Yoko
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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Aniya Yoko
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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Kunii Daisuke
Laboratory Of Functional And Molecular Pharmacology Graduate School Of Medicine University Of The Ry
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Kunii Daisuke
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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GYAMFI Maxwell
Laboratory of Physiology and Pharmacology, School of Health Sciences, University of the Ryukyus,
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TAKAYAMA Fusako
Department of Pharmacology, Oita Medical University
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Gyamfi Maxwell
琉球大学 保健
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Gyamfi Maxwell
Laboratory Of Physiology And Pharmacology School Of Health Sciences University Of The Ryukyus
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Miyagi Chika
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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SHIMABUKURO Minako
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, Universit
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SHIMOJI Manami
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, Universit
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KOHATSU Mayumi
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, Universit
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Takayama F
Oita Medical Univ. Oita Jpn
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Takayama Fusako
Department Of Pharmacology
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Shimoji M
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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Kohatsu Mayumi
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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Shimabukuro Minako
Laboratory Of Physiology And Pharmacology School Of Health Sciences Faculty Of Medicine University O
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Shimoji Minami
Laboratory of Physiology and Pharmacology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus
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