Changes in amine oxidase in plasma of rats treated with hepatotoxins.
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概要
- 論文の詳細を見る
When allyl formate (AF) was administered to rats, the marked elevation of B-form MAO activity in plasma was found with β-PEA as a substrate. In contrast, in the case of carbon tetrachloride (CCl<SUB>4</SUB>), A-form MAO activity elevated predominantly. The deaminations of 5-HT and β-PEA in these plasma treated with AF or CCl<SUB>4</SUB> were not inhibited completely by a high concentration of MAO inhibitor, deprenyl or clorgyline. These results indicate the there may be two or more distinct amine oxidases released from the liver and other organs in response to CCl<SUB>4</SUB> or AF.
- 公益社団法人 日本薬理学会の論文
著者
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Obata Toshio
Department Of Analytical Chemistry School Of Pharmaceutical Sciences Ohu University
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Yamanaka Yasumitsu
Department Of Pharmacology Oita Medical University
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