Effect of bifemelane hydrochloride on an injury of the liver caused by ischemia-reperfusion in rats.
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概要
- 論文の詳細を見る
In the liver ischemia-reperfusion model, the lipid peroxide level increased during ischemic periods, while a greater increase was observed during reflow periods. The increase in the cytochrome b<SUB>5</SUB> content was observed during ischemia and reflow periods. On the contrary, the cytochrome P-450 content remained unchanged during ischemic periods, but decreased during reflow periods. Bifemelane suppressed the elevation of the lipid peroxide level, the cytochrome b<SUB>5</SUB> content and the decrease in cytochrome P-450 content during the period of reperfusion.
- 公益社団法人 日本薬理学会の論文
著者
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Yamanaka Yasumitsu
Department Of Pharmacology Oita Medical University
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Nagai Takayuki
Department of Basic Research, Oriental Medicine Research Center, Kitasato University
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