Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats
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概要
- 論文の詳細を見る
The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2-), hydroxyl radicals (·OH) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for Ka (absorption rate constant), Tmax (peak concentration time), T1/2 (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.
- 社団法人 日本薬理学会の論文
- 1999-08-01
著者
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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KOMATSU Yasuhiro
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.,
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Komatsu Yasuhiro
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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YAMANAKA YASUMITSU
Medical College of Oita
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Yamanaka Yasumitu
Department Of Pharmacology Oita Medical University
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Yamanaka Yasumitsu
Depts. Of Pharmacology Medical College Of Oita
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Yamanaka Yasumitsu
Department Of Pharmacology Oita Medical University
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Egashira Toru
Dept. Pharmacol. Med. College Of Oita
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Yamanaka Y
Department Of Pharmacology Oita Medical University
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TAKAYAMA Fusako
Department of Pharmacology, Oita Medical University
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Egashira T
Oita Medical Univ. Oita Jpn
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Takayama Fusako
Department Of Pharmacology Oita Medical University
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Takayama Fusako
Department Of Pharmacology
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Komatsu Yasuhiro
Kampo & Pharmacognosy Laboratory Tsumura & Co.
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Egashira Toru
Dept. Of Pharmacol. Oita Med. U.
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Takayama Fusako
Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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