Mechanisms by Which Hange-shashin-to Reduces Prostaglandin E2 Levels
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概要
- 論文の詳細を見る
To determine the mechanisms by which Hange-shashin-to (TJ-14) reduces prostaglandin E2 (PGE2) levels, the effects on blood corticosterone levels were examined in vivo and the effects on cyclooxygenase (COX) activity in virto assessed. TJ-14,orally administered to rats at dose levels between 125 and 1000 mg/kg, caused a dose-dependent increase in blood corticosterone levels. We also showed that Glycyrrhizae Radix and Ginseng Radix, constituents of TJ-14,are involved in the increase in blood corticosterone. The activity of COX-1 was not inhibited by TJ-14 even at a dose of 1000 μg/ml, while COX-2 was inhibited at dose levels between 10 and 1000 μg/ml. The constituents Scutellariae Radix, Glycyrrhizae Radix and Coptidis Rhizoma were believed to be involved in COX-2 inhibition.These results suggest that the effect of TJ-14 in decreasing PGE2 is partially mediated by corticosterone and inhibition of COX-2.
- 公益社団法人日本薬学会の論文
- 1998-12-15
著者
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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KOMATSU Yasuhiro
Kampo and Pharmacognosy Laboratory, Tsumura Central Laboratories, Tsumura & Co.,
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石毛 敦
ツムラ研究本部 医薬評価研究所
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige A
Tsumura Res. Inst. Ibaraki Jpn
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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加瀬 義夫
津村薬理研究所
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KASE Yoshio
Kampo & Parmacognosy Laboratory, Tsumura & Co.
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SAITOH Kazuko
Kampo Pharmacology Department, Kampo & Pharmacognosy Laboratory, Central Research Laboratories, Tsum
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Saito Kazuko
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
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Komatsu Yasuhiro
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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KASE Yoshiko
Kampo Pharmacology Department II, Pharmacognosy Laboratory
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Iizuka A
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Kampo & Pharmacognosy Laboratory Tsumura & Co.
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Saitoh K
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Ishige Atsushi
Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
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