Mechanism of Atropine-Resistant Contraction Induced by Dai-kenchu-to in Guinea Pig Ileum
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the contractile mechanism of Dai-kenchu-to, the effects of hydroxy β-sanshool (an ingredient of Zanthoxylum fruit), Zanthoxylum fruit (a constituent herb of Dai-kenchu-to) and Dai-kenchu-to were studied in mucosa-free longitudinal muscle of guinea pig ileum. Hydroxy β-sanshool at 10−7 - 10 −5 g/ml induced dose-related contractions accompanied by autonomous contraction and produced an initial contraction at a concentration of 10−4 g/ml or more. The contraction induced by hydroxy β-sanshool (10−5 g/ml) was significantly inhibited by tetrodotoxin or the capsaicin-receptor antagonist capsazepine. Although atropine or the substance P antagonist spantide tended to inhibit the contraction, a combination of atropine and spantide almost abolished the contraction by hydroxy β-sanshool. The P2-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2,4-disulphonic acid did not affect hydroxy β-sanshool-induced contraction in the presence or absence of spantide. The tonic contractions by Zanthoxylum fruit (2 × 10−4 g/ml) and Dai-kenchu-to (10−3 g/ml) were significantly inhibited or tended to be inhibited by atropine, spantide, tetrodotoxin or capsazepine and were remarkably suppressed by the combination of atropine and spantide. These results suggested that acetylcholine release from intrinsic cholinergic nerves and tachykinins from sensory neurons are involved in the contractions induced by hydroxy β-sanshool and that tachykinins may be involved in the atropine-resistant contraction by Dai-kenchu-to.
- 社団法人 日本薬理学会の論文
- 2001-05-01
著者
-
石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
-
Hashimoto Kazunori
Kainpo & Pharmacognosy Laboratory Tsumura & Co.
-
Hashimoto Kazunori
ツムラ漢方生薬研究所
-
石毛 敦
ツムラ研究本部 医薬評価研究所
-
Ishige A
Tsumura Res. Inst. Ibaraki Jpn
-
Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
-
Ishige Atsushi
北陸大学 薬 薬物治療
-
Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
-
SATOH Kazuko
Kampo & Pharmacognosy Laboratory, R&D Division, Tsumura & Co.
-
HAYAKAWA Terumasa
Kampo & Pharmacognosy Laboratory, R&D Division, Tsumura & Co.
-
HASHIMOTO Kazunori
Kampo & Pharmacognosy Laboratory, R & D Division, Tsumura & Co.
-
KANEKO Misao
The Third Department of Internal Medicine, Teikyo University, School of Medicine (Ichihara Hospital)
-
OGIHARA Soichiro
The Third Department of Internal Medicine, Teikyo University, School of Medicine (Ichihara Hospital)
-
KUROSAWA Susumu
The Third Department of Internal Medicine, Teikyo University, School of Medicine (Ichihara Hospital)
-
YAKABI Koji
The Third Department of Internal Medicine, Teikyo University, School of Medicine (Ichihara Hospital)
-
NAKAMURA Takashi
The Third Department of Internal Medicine, Teikyo University, School of Medicine (Ichihara Hospital)
-
Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
-
Saito Kazuko
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
-
Nakamura Tokiko
4th Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Hashimoto K
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University.
-
Sakai Kyoko
Center For Digestive And Liver Diseases Nara City Hospital
-
Iizuka A
Central Research Laboratories Tsumura & Co
-
Hayakawa T
National Inst. Health Sci. Tokyo Jpn
-
Yakabi Koji
Saitama Medical Univ. Saitama Jpn
-
Kaneko Misao
The Third Department Of Internal Medicine Teikyo University School Of Medicine (ichihara Hospital)
-
Kurosawa Susumu
Teikyo Univ. School Of Medicine Ichihara Jpn
-
Hayakawa T
Tsumura Res. Inst. Medicinal Evaluation Lab. Ibaraki Jpn
-
Hayakawa T
Central Research Laboratories Tsumura & Co.
-
Ohno Shino
Department Of Internal Medicine Teikyo University Ichihara Hospital
-
Ohno Shino
Department Of Gastroenterology And Hepatology Saitama Medical Center Saitama Medical University
-
Nakamura Takashi
Department Of Internal Medicine Teikyo University Ichihara Hospital
-
Saitoh K
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
-
Ishige Atsushi
Kampo & Pharmacognosy Laboratory R & D Division, Tsumura & Co.
-
NAKAMURA Takashi
The Third Department of Internal Medicine, Teikyo University School of Medicine
関連論文
- 23 小青竜湯のモルモット実験的アレルギー性鼻炎に対する作用 : Acoustic rhinometerを用いた評価
- 2G178 El-マウス神経細胞の特色
- P-12 更年期 Hot Flush 実験モデルにおける当帰芍薬散, 加味逍遥散, 桂枝茯苓丸の作用比較検討
- 1. 大建中湯の腸管機能に対する作用と活性成分(第 6 回小児外科漢方研究会)
- II-B-7 芍薬甘草湯の運動機能に及ぼす影響第 1 報 : 筋痙縮モデルに対する作用
- G-3 El マウスの攻撃行動に対する柴胡加竜骨牡蠣湯の作用
- 330 苓甘姜味辛夏仁湯の薬理作用の特徴
- 329 小青竜湯の抗アレルギー作用
- P-50 柴胡桂枝湯の各種肝障害モデルに及ぼす影響
- MS-IV-1 柴胡桂枝湯の各種肝障害モデルに及ぼす影響
- 1. 六君子湯の胃機能に対する作用(第 5 回 小児外科漢方研究会)
- 138 葛根湯加川キュウ辛夷の抗アレルギー作用の検討
- P-23 ワルファリンと数種漢方薬の併用による血液凝固系に及ぼす影響
- General Pharmacological Properties of Dai-kenchu-to Extract
- General Pharmacological Properties of Daio-kanzo-to
- P-47 受動的回避課題における scopolamine 健忘に対する補剤の作用
- P-14 当帰芍薬散の卵巣摘出モデルにおける睡眠障害に対する作用検討
- General Pharmacological Properties of Hochu-ekki-to
- General Pharmacological Properties of Shakuyaku-kanzo-to
- General Pharmacological Properties of Choto-san extracts
- Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C
- An Herbal Medicine Orengedokuto Prevents Indomethacin-Induced Enteropathy(Pharmacology)
- Pharmacological Characteristics of Ryokan-Kyomi-shinge-nin-to, an Antiallergic Kampo Medicine
- Pharmacological Evaluation of Shokyo and Kankyo (1)
- Dai-kenchu-to Enhances Accelerated Small Intestinal Movement
- Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine
- Anti-CD3 induces bi-phasic apoptosis in murine intestinal epithelial cells : possible involvement of the Fas/Fas ligand system in different T cell compartments
- Possible Involvement of Suppression of Th2 Differentiation in the Anti-allergic Effect of Sho-seiryu-to in Mice
- Mechanism of Atropine-Resistant Contraction Induced by Dai-kenchu-to in Guinea Pig Ileum
- Pharmacological Studies of the Effect of Dai-kenchu-to on Spontaneous Contraction of Isolated Rabbit Jejunum
- Effects of Dai-kenchu-to on Intestinal Obstruction Following Laparotomy
- Effects of Keishi-ka-shakuyaku-to (Gui-Zhi-Jia-Shao-Yao-Tang) on Diarrhea and Small Intestinal Movement
- Effects of Hange-shashin-to on Cholera Toxin-Induced Fluid Secretion in the Small Intestine of Rats
- The Effects of Hange-shashin-to on the Content of Prostaglandin E_2 and Water Absorption in the Large Intestine of Rats
- Pharmacological Studies on Antidiarrheal Effects of Hange-Shashin-To
- Ex vivo large-scale generation of human red blood cells from cord blood CD34^+ cells by co-culturing with macrophages
- Suppressive effect of ethanol on the expression of hepatic asialoglycoprotein receptors augmented by interleukin-1β,interleukin-6, and tumor necrosis factor-α
- Lower circulating levels of dehydroepiandrosterone, independent of insulin resistance, is an important determinant of severity of non-alcoholic steatohepatitis in Japanese patients
- Cloning of the cDNA for a Mouse Homologue of Human PHBP : a Novel Hyaluronan-Binding Protein
- Isolation and Characterization of the Plasma Hyaluronan-Binding Protein (PHBP) Gene (HABP2)
- Molecular Cloning and Expression of Human Liver Biliverdin-IXβ Reductase
- Isolation and Characterization of the Human Inter-α-Trypsin Inhibitor Family Heavy Chain-Related Protein (IHRP) Gene (ITIHL1)
- Primary Structure of the Pig Homologue of Human IHRP: Inter-α-Trypsin Inhibitor Family Heavy Chain-Related Protein
- Inhibitory Effect of Coptidis Rhizoma and Scutellariae Radix on Azoxymethane-Induced Aberrant Crypt Foci Formation in Rat Colon
- Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C
- Correlation of hepatic steatosis with body mass index, serum ferritin level and hepatic fibrosis in Japanese patients with chronic hepatitis C
- Effect of iron reduction by phlebotomy in Japanese patients with nonalcoholic steatohepatitis : A pilot study
- Sairei-to enhances the antinephrotic effect of cyclosporine A in puromycin aminonucleoside-treated rats
- 30B-01 老齢ラットのコリン作働性神経機能に対する当帰芍薬散の効果について
- I-C-6 Streptozotocin 誘発糖尿病マウスにおける牛車腎気丸の抗侵害受容作用の増強
- Effect of Choto-san, a Kampo Medicine, on the Cerebral Blood Flow Autoregulation in Spontaneously Hypertensive Rats
- Antinociceptive Mechanism of Gosha-jinki-gan in StreptozotocinInduced Diabetic Animals: Role of Nitric Oxide in the Periphery
- Analgesia-Producing Mechanism of Processed Aconiti Tuber-Role of Dynorphin an Endogenous k-Opioid Ligand,in the Rodent Spinal Cord
- Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice
- Effect of Gosha-jinki-gan, a Kampo Medicine, on Enhanced Platelet Aggregation in Streptozotocin-Induced Diabetic Rats
- Mechanisms by Which Hange-shashin-to Reduces Prostaglandin E2 Levels
- The Effects of Hange-shashin-to on Gastric Function in Comparison with Sho-saiko-to
- Preventive Effects of Hange-shashin-to on Irinotecan Hydrochloride-Caused Diarrhea and Its Relevance to the Colonic Prostaglandin E_2 and Water Absorption in the Rat
- Simultaneous determination of glucocorticoids in plasma or urine by high-performance liquid chromatography with precolumn fluorimetric derivatization by 9-anthroyl nitrile
- A Predictive Model for Area Under the Concentration versus Time Curve of Cyclosporin A Using Several Routine Monitoring Results in Renal Transplant Patients
- Cloning and Characterization of cDNA for Inter-α-Trypsin Inhibitor Family Heavy Chain-Related Protein (IHRP), a Novel Human Plasma Glycoprotein
- Anti-type I Allergic Mechanisms of Mao-bushi-saishin-to in Mice
- Relevance of Irinotecan Hydrochloride-Induced Diarrhea to the Level of Prostaglandin E_2 and Water Absorption of Large Intestine in Rats
- Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis
- Effect of interleukin-8 on histamine release from totally isolated vascularly perfused rat stomach
- Superior mesenteric arterial embolism : treatment by trans-catheter thrombo-aspiration
- Effects of interleukin-8 and Helicobacter phylori on histamine release from isolated canine gastric mucosal cells
- A Case of Esophagitis Associated with Stevens-Johnson's Syndrome
- Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach
- Fitz-Hugh-Curtis Syndrome : Hepatic Capsular Enhancement and Diffuse Gallbladder Wall Thickening on Contrast-Enhanced CT
- A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan