Effects of Dai-kenchu-to on Intestinal Obstruction Following Laparotomy
スポンサーリンク
概要
- 論文の詳細を見る
To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation of the effects of Dai-kenchu-to on postoperative intestinal adhesion was conducted. Repeated administrations of Dai-kenchu-to (100 or 300 mg/kg) significantly inhibited the formation of intestinal obstruction. Motor disturbance and inflammation are thought to be involved in the etiology of intestinal adhesion. A single treatment of Dai-kenchu-to (300mg/kg) significantly reduce intestinal transit time in postoperative ileus and chemically-induced ileus. Dai-kenchu-to (10^<-4> g/ml) significantly inhibited COX-2 activity. These results suggest that Dai-kenchu-to prevents postoperative intestinal adhesion by gastroprokinetic and anti-inflammatic effects. Dai-kenchu-to thus demonstrates positive effect on postoperative ileus.
- 日本平滑筋学会の論文
著者
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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Hashimoto Kazunori
Kainpo & Pharmacognosy Laboratory Tsumura & Co.
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Hashimoto Kazunori
ツムラ漢方生薬研究所
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石毛 敦
ツムラ研究本部 医薬評価研究所
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige A
Tsumura Res. Inst. Ibaraki Jpn
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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加瀬 義夫
津村薬理研究所
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ISHIGE Atsushi
Central Research Laboratories, Tsumura & Co.
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HAYAKAWA Terumasa
Central Research Laboratories, Tsumura & Co.
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SAITO Kazuko
Central Research Laboratories, Tsumura & Co.
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HASHIMOTO Kazunori
Central Research Laboratories, Tsumura & Co.
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KOMATSU Yasuhiro
Central Research Laboratories, Tsumura & Co.
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SASAKI Hiroshi
Central Research Laboratories, Tsumura & Co.
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Ishige Atsushi
Central Research Laboratories Tsumura & Co
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Saito Kazuko
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
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Hashimoto K
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University.
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Komatsu Yasuhiro
Central Research Laboratories Tsumura & Co
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Sasaki Horoshi
Faculty of Agriculture, Tohoku University
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Iizuka A
Central Research Laboratories Tsumura & Co
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Hayakawa T
National Inst. Health Sci. Tokyo Jpn
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Hayakawa T
Tsumura Res. Inst. Medicinal Evaluation Lab. Ibaraki Jpn
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Hayakawa T
Central Research Laboratories Tsumura & Co.
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Sasaki H
Tsumura Research Institute Tsumura & Co.
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Sasaki Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Sasaki Hiroshi
金沢大学 自然科学研究科臨床薬学
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Saitoh K
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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