Goshuyuto, a Traditional Japanese Medicine for Migraine, Inhibits Platelet Aggregation in Guinea-Pig Whole Blood

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概要

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• The effects of goshuyuto and chotosan, traditional Japanese medicines, on collagen-induced platelet aggregation were examined using guinea-pig blood. Goshuyuto at the concentration of 1,000 μg/mL inhibited collagen-induced platelet hyper-aggregation to the same degree as aspirin at the concentration of 100 μM, but chotosan did not. Goshuyuto is composed of four medicinal herbs. Of them, aqueous extracts of Evodiae Fructus and Zingiberis Rhizoma inhibited platelet aggregation, but aqueous extracts of Zizyphi Fructus and Ginseng Radix did not. Two components of Zingiberis Rhizoma, 6-shogaol and 6-gingerol, also inhibited platelet aggregation. These results suggest that Evodiae Fructus and Zingiberis Rhizoma may play important roles in the anti-aggregation effects of goshuyuto and that 6-shogaol and 6-gingerol are among the active ingredients. Therefore, goshuyuto may ameliorate migraine by preventing the hyper-aggregation of platelets in migraine with aura.

• 社団法人 日本薬理学会の論文
• 2008-09-20

著者

• TAKEDA Atsushi

  Department of Computer Science, Tohoku Bunka Gakuen University

• Kase Y

  Tsumura Research Laboratories Tsumura & Co.

• Kase Yoshio

  ツムラ漢方生薬研究所

• Kase Yoshio

  国立長寿医療センター研究所 老年病研究部

• Kase Yoshio

  Central Research Laboratory Tsumura & Co.

• 加瀬 義夫

  津村薬理研究所

• HIBINO Tomoko

  Tsumura Research Laboratories, Tsumura & Co.

• YUZURIHARA Mitsutoshi

  Tsumura Research Laboratories, Tsumura & Co.

• KASE Yoshio

  Tsumura Research Laboratories, Tsumura & Co.

• KANNO Hitomi

  Tsumura Research Laboratories, Tsumura & Co.

• TERAWAKI Kiyoshi

  Tsumura Research Laboratories, Tsumura & Co.

• Yuzurihara Mitsutoshi

  Tsumura Research Laboratories Tsumura & Co.

• Yuzurihara Mitsutoshi

  Central Research Laboratory Tsumura & Co.

• Yuzurihara Mitsutoshi

  Kampo & Parmacognosy Laboratory Tsumura & Co.

• Kanno Hitomi

  Tsumura Research Laboratories Tsumura & Co.

• Mizuhara Yasuharu

  Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo

• Kase Yoshio

  ツムラツムラ研究所

• Kase Yoshio

  Tsumura Research Institute Medicinal Evaluation Laboratory

• Hibino Tomoko

  Tsumura Research Laboratories Tsumura & Co.

• Takeda Atsushi

  Department Of Medical Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka

• Takeda Atsushi

  Department Of Clinical Pathology Showa University Fujigaoka Hospital Showa University School Of Medi

• Yuzurihara Mitsutoshi

  Tsumura & Co.

• Terawaki Kiyoshi

  Tsumura Research Laboratories Tsumura & Co.

• TAKEDA Atsushi

  Department of Clinical Pathology Showa University Fujigaoka Hospital

• Kase Yoshio

  Tsumura & Co., Tsumura Research Laboratories

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