The Effect of Herbal Medicine Toki-shakuyaku-san on Blood Pressure in an N^ω-Nitro-L-Arginine Methyl Ester-Induced Pre-eclampsia Rat Model During Pregnancy and the Postpartum Period

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概要

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• The chronic inhibition of nitric oxide (NO) synthesis with Nω-nitro-<sc>L</sc>-arginine methyl ester (<sc>L</sc>-NAME) in pregnant rats induces a pre-eclampsia-like syndrome, including hypertension. We have previously reported the beneficial effects of Toki-shakuyaku-san (TS) in this model. In the present study we demonstrated the anti-hypertensive effect of TS in pre-eclampsia produced by prolonged <sc>L</sc>-NAME-infusion during the postpartum period. Analysis of blood sex steroids suggested that the level of progesterone differs between the TS-effective (gestational day 19 and postpartum day 7) and TS-ineffective (postpartum day 1) periods. Co-administration of TS and progesterone inhibited <sc>L</sc>-NAME-induced hypertension on postpartum day 1. Furthermore, the anti-hypertensive effect of TS on postpartum day 6 disappeared in the presence of a co-administered progesterone antagonist mifepristone. These data suggest that a certain level of progesterone may be an indispensable prerequisite for an anti-hypertensive effect of TS. Finally, the effects of TS are apparently unrelated to blood levels of NO, calcitonin gene-related peptide, and endothelin-1, which have been reported to modulate systolic blood pressure in the <sc>L</sc>-NAME-induced pre-eclampsia model. Thus, the use of TS may provide a new therapeutic strategy for pre-eclampsia, although elucidation of the mechanism of action of TS would be necessary to optimize treatment protocols.

• 社団法人 日本薬理学会の論文
• 2005-07-20

著者

• Kase Y

  Tsumura Research Laboratories Tsumura & Co.

• Kase Yoshio

  ツムラ漢方生薬研究所

• Kase Yoshio

  国立長寿医療センター研究所 老年病研究部

• Kase Yoshio

  Central Research Laboratory Tsumura & Co.

• 加瀬 義夫

  津村薬理研究所

• KASE Yoshio

  Tsumura Research Laboratories, Tsumura & Co.

• TAKEDA Shuichi

  Tsumura and Co., Pharmacology Research Department, R&D Division

• YAMAMOTO Masahiro

  Tsumura Research Institute, Tsumura & Co.

• 竹田 秀一

  Tsumura & Co. Tsumura Res. Laboratories

• Yamamoto Masako

  Department Of Anatomy Ii School Of Veterinary Medicine Azabu University

• Yamamoto Masaru

  Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ

• TAKEI Hisato

  Tsumura Research Institute, Tsumura and Co.

• Kase Yoshio

  ツムラツムラ研究所

• Kase Yoshio

  Tsumura Research Institute Medicinal Evaluation Laboratory

• Takei Hisato

  Tsumura Research Institute Tsumura And Co.

• Yamamoto Masaru

  Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ

• Yamamoto Masahiro

  Center For Kampo Medicine Keio University School Of Medicine

• Takeda Shuichi

  Tsumura & Co. Tsumura Research Laboratories

• Yamamoto Masahiro

  Tsumura Research Institute Tsumura & Co.

• Kase Yoshio

  Tsumura & Co., Tsumura Research Laboratories

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