Effects of Maternal Exposure to Diethylstilbestrol on Epididymal Development in Rat Offspring(Anatomy)
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概要
- 論文の詳細を見る
In our previous study, prenatal diethylstilbestrol (DES) exposure (days 7-21 of gestation) suppressed plasma testosterone levels and histological development in the epididymis of rat offspring. In this study, we measured cell proliferation in epididymal ductules and the expression of steroid hormone receptors and 5α-reductase 1 in the epididymis to assess the effect of DES on epididymal development in the offspring. Prenatal DES exposure did not alter the cell division index, but suppressed the expression of androgen receptor mRNA at 15 weeks after birth, and stimulated estrogen receptor α mRNA at 6 weeks. These results suggest that prenatal DES exposure results in the retardation of epididymal tissue maturation by disruption of the postnatal expression of steroid hormone receptors.
- 社団法人日本獣医学会の論文
- 2009-03-25
著者
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KOBAYASHI Tetsuo
Department of Anatomy II School of Veterinary Medicine, Azabu University
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SHIRAI Mitsuyuki
Department of Veterinary Pharmacology School of Veterinary Medicine, Azabu University
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ARISHIMA Kazuyoshi
Department of Anatomy II School of Veterinary Medicine, Azabu University
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YAMAMOTO Masako
Department of Anatomy II School of Veterinary Medicine, Azabu University
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Yamamoto Masako
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Shirai Mitsuyuki
School Of Veterinary Medicine Azabu University
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Shirai Mitsuyuki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Veterinary Anatomy Ii Azabu University School Of Veterinary Medicine
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Arishima Kazuyoshi
Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Shiota K
Kyoto Univ. Graduate School Of Medicine Kyoto Jpn
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Sugita Kana
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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NISIKAWA Osamu
Department of Electronic Engineering, Kanazawa Institute of Technology
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KOHARA Shinya
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Yamamoto Masako
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Kobayashi Tetsuo
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Kohara Shinya
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Nisikawa Osamu
Department Of Anatomy School Of Veterinary Medicine
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Yamamoto Masahiro
Center For Kampo Medicine Keio University School Of Medicine
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ARISHIMA Kazuyoshi
Department of Anatomy II
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SHIRAI Mitsuyuki
Department of Pharmacology, Azabu University School of Veterinary Medicine
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KOBAYASHI Tetsuo
Department of Anatomy II
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