Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice
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概要
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The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Leprfa (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.
著者
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Kaji Noriyuki
Department Of Neuropsychiatry Kinki University School Of Medicine
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Takahashi Saya
Department Of Food Science Faculty Of Dairy Science Rakuno Gakuen University
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ASAI Fumitoshi
Department of Pharmacology, Azabu University School of Veterinary Medicine
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HIRAI Norihiko
Department of Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252–5201, Japan
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SHIRAI Mitsuyuki
Department of Pharmacology, Azabu University School of Veterinary Medicine
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NAGAKUBO Dai
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
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HASHIDA Shin-ichi
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
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KURATANI Motoi
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
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