Plasma Profiles of Glucose, Insulin and Lipids in the Male WBN/Kob-Leprfa Rat, a New Model of Type 2 Diabetes with Obesity
スポンサーリンク
概要
- 論文の詳細を見る
Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Leprfa (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.
著者
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Shirai Mitsuyuki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University
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Kaji Noriyuki
Department Of Neuropsychiatry Kinki University School Of Medicine
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ASAI Fumitoshi
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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OKUNO Akira
Shinagawa R Center, Daiichi-Sankyo Co., Ltd., 1–2–58 Hiromachi, Shinagawa-ku, Tokyo 140–8710, Japan
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OHNO-ICHIKI Kanako
Shinagawa R Center, Daiichi-Sankyo Co., Ltd., 1–2–58 Hiromachi, Shinagawa-ku, Tokyo 140–8710, Japan
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OKI Hisako
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
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ISHIZAWA Haruya
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan
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OHNO-ICHIKI Kanako
Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd.
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ASAI Fumitoshi
Department of Pharmacology, Azabu University School of Veterinary Medicine
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OKUNO Akira
Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd.
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OKI Hisako
Department of Pharmacology, Azabu University School of Veterinary Medicine
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SHIRAI Mitsuyuki
Department of Pharmacology, Azabu University School of Veterinary Medicine
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ISHIZAWA Haruya
Department of Pharmacology, Azabu University School of Veterinary Medicine
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