EFFECTS OF MATERNAL EXPOSURE TO DIETHYLSTILBESTROL ON THE DEVELOPMENT OF THE REPRODUCTIVE SYSTEM AND THYROID FUNCTION IN MALE AND FEMALE RAT OFFSPRING
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概要
- 論文の詳細を見る
Diethyistilbestrol (DES) was administered subcutaneously at 1.5 or 15 μg/kg/day (DES 1.5 group, DES 15 group) to pregnant SD rats daily on days 7-21 of gestation to investigate its effects on the development and functions of the reproductive system and thyroid gland in their offspring. Of the 11 pregnant rats in the DES 15 group, only one delivered a live pup. Rat pups in the DES 1.5 group were autopsied at 1, 3, or 6 weeks after birth. In the DES 1.5 group, the plasma T4 concentrations at all weeks of age at autopsy were significantly increased, the TSH concentration at 6 weeks of age was also significantly increased, and the height of thyroid follicular epithelial cells was increased at 3 weeks. The testosterone concentration in the DES 1.5 group at 6 weeks was significantly decreased and the plasma LH concentration was increased. The DES treatment increased the plasma FSH concentration in female pups at 3 weeks, increased the percentages of primary and secondary ovarian follicles, and decreased the percentage of primordial follicles, but did not influence the timing of the vaginal opening or the onset of the estrous cycle. These observations indicate that prenatally administered DES increases thyroid function, and has an inhibitory effect on testicular function and a promoting effect on female reproductive function.
- 日本トキシコロジー学会の論文
- 2003-12-26
著者
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SHIRAI Mitsuyuki
Department of Veterinary Pharmacology School of Veterinary Medicine, Azabu University
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ARISHIMA Kazuyoshi
Department of Anatomy II School of Veterinary Medicine, Azabu University
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YAMAMOTO Masako
Department of Anatomy II School of Veterinary Medicine, Azabu University
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YAMAMOTO Kentaro
Department of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Kyoto University
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Tamura Aya
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Masako
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Shirai Mitsuyuki
School Of Veterinary Medicine Azabu University
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Shirai Mitsuyuki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Veterinary Anatomy Ii Azabu University School Of Veterinary Medicine
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Arishima Kazuyoshi
Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Shiota K
Kyoto Univ. Graduate School Of Medicine Kyoto Jpn
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Sugita Kana
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Shiota Kohei
Department Of Anatomy And Congenital Anomaly Research Center Faculty Of Medicine Kyoto University
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Yamamoto K
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Nagai Naoko
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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MIURA Yumi
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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MOGI Ryota
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Yamamoto Masako
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Kentaro
Department Of Molecular Microbiology Graduate School Of Pharmaceutical Sciences Kyoto University
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Kohara Shinya
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Miura Yumi
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Mogi Ryota
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Masahiro
Center For Kampo Medicine Keio University School Of Medicine
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TAMURA Aya
Department of Anatomy II
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YAMAMOTO Kentaro
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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ARISHIMA Kazuyoshi
Department of Anatomy II
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SHIRAI Mitsuyuki
Department of Pharmacology, Azabu University School of Veterinary Medicine
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