DILATING EFFECT OF PROSTAGLANDIN ON THE CONSTRICTED DUCTUS ARTERIOSUS IN NEWBORN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The dilating effect of prostaglandin (PG) E_1 and E_2 on the once-constricted ductus arteriosus (DA) was examined in newborn rats. The animals were given subcutaneously PGs 3hr after caesarean delivery. The ratio of the DA to the pulmonary artery (PA) was determined 15, 30, 60, 90 and 180 min after injection. Both PGE_1 and PGE_2 dilated the DA for over 90 min. The maximal effect appeared 15 or 30 min after injection. The DA/PA ratio was significantly higher in PGE_2 than in PGE_1. In addition, another series of newborn rats were given subcutaneously PGE_2 6 hr after caesarean delivery to examine the age-related changes in the DA-dilating effect. The DA/PA ratio was significantly decreased in 6-hr-old pups than in 3-hr-old pups. These findings indicate that both PGE_1 and PGE_2 have a dilating effect on the once-constricted DA and that the effect decreases with time.
- 日本トキシコロジー学会の論文
- 1995-02-25
著者
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ARISHIMA Kazuyoshi
Department of Anatomy II School of Veterinary Medicine, Azabu University
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YAMAMOTO Masako
Department of Anatomy II School of Veterinary Medicine, Azabu University
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Somiya Hiroaki
Department of LifeSciences, Faculty of Bioresources, Mie University
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Takagi Hironori
Toxicology Laboratory Drug Metabolism And Toxicology Research Center Taisho Pharmaceutical Co. Ltd.
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Somiya H
Departments Of Developmental Biotechnology Azabu University School Of Veterinary Medicine
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TAKIZAWA Tatsuya
Departments of Developmental Biotechnology, Azabu University, School of Veterinary Medicine
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IKEDA Yoshinori
Departments of Developmental Biotechnology, Azabu University, School of Veterinary Medicine
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TOGASHI Hirofumi
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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NAMBA Yasuhiro
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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EGUCHI Yasunobu
Department of Anatomy II, Azabu University, School of Veterinary Medicine
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Yamamoto Masako
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Veterinary Anatomy Ii Azabu University School Of Veterinary Medicine
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Arishima Kazuyoshi
Anatomy Ii School Of Veterinary Medicine Azabu University
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Arishima Kazuyoshi
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Takagi H
Toxicology Laboratory Drug Metabolism And Toxicology Research Center Taisho Pharmaceutical Co. Ltd.
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Namba Yasuhiro
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Somiya Hiroaki
Department Of Lifesciences Faculty Of Bioresources Mie University
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Togashi H
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Eguchi Yasunobu
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Ikeda Yoshinori
Department Of Materials Science And Engineering Tokyo Institute Of Technology
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Yamamoto Masako
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Yamamoto Masahiro
Center For Kampo Medicine Keio University School Of Medicine
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Togashi H
Department Of Anatomy Ii Azabu University School Of Veterinary Medicine
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Ikeda Yoshinori
Department of Developmental Biotechnology, Azabu University School of Veterinary Medicine
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ARISHIMA Kazuyoshi
Department of Anatomy II
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Togashi Hirofumi
Department of Anatomy II, Azabu University School of Veterinary Medicine
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TAKIZAWA Tatsuya
Departments of Developmental and Reproductive Biotechnology, Azabu University School of Veterinary Medicine, Fuchinobe, Sagamihara-shi, Kanagawa 229-8501, Japan
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