An Herbal Medicine Orengedokuto Prevents Indomethacin-Induced Enteropathy(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Prostaglandin E2 (PGE2) is a key regulator of gastrointestinal, immunological, and mucosal homeostasis. Non-steroidal anti-infiammatory drugs (NSAIDs) inhibit the prostaglandin-producing enzyme cyclooxygenases (COXs), and can induce serious complications, such as gastrointestinal damage, with long-term treatment. Orengedokuto (OGT), a Japanese traditional herbal medicine (Kampo medicine), is effective in various animal models of enteropathy. In the present study we examined whether OGT prevents enteropathy induced by NSAIDs in mice. Ulceration in the small intestine was induced with 2 subcutaneous injections of indomethacin (20 mg/kg body weight). Orally administered OGT prevented or reduced lethality, intestinal lesions, bleeding, increased serum nitrate/nitrite levels, and reduction of mucosal PGE2 induced by indomethacin. These beneficial effects of OGT were accompanied by increased production of PGE2 and interleukin 10 by isolated lamina propria mononuclear cells; COX-2 in these cells may be a major source of PGE2 in normal intestines. These findings suggest that OGT could be an effective therapeutic agent for the treatment of inflammatory bowel disease and adverse reactions to NSAIDs.
- 社団法人日本薬学会の論文
- 2007-03-01
著者
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竹田 秀一
ツムラ研究本部
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石毛 敦
(株)ツムラ中央研究所
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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Nakai Yoichiro
Central Research Laboratories Tsumura & Co.
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石毛 敦
ツムラ研究本部 医薬評価研究所
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ISHIGE Atsushi
株式会社ツムラ 研究本部 医薬評価研究所
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラ漢方生薬研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige A
Tsumura Res. Inst. Ibaraki Jpn
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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加瀬 義夫
津村薬理研究所
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MIURA Naoko
Central Research Laboratories, Tsumura & Co.
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FUKUTAKE Masato
Central Research Laboratories, Tsumura & Co.
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YAMAMOTO Masahiro
Central Research Laboratories, Tsumura & Co.
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OHTAKE Nobuhiro
Central Research Laboratories, Tsumura & Co.
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IIZUKA Seiichi
Central Research Laboratories, Tsumura & Co.
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IMAMURA Sachiko
Central Research Laboratories, Tsumura & Co.
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TSUCHIYA Naoko
Central Research Laboratories, Tsumura & Co.
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ISHIMATSU Makoto
Central Research Laboratories, Tsumura & Co.
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NAKAMURA Yuichi
Central Research Laboratories, Tsumura & Co.
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ISHIGE Atsushi
Department of Kampo Medicine, Keio University, School of Medicine
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WATANABE Kenji
Department of Kampo Medicine, Keio University, School of Medicine
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TAKEDA Shuichi
Central Research Laboratories, Tsumura & Co.
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MIURA Naoko
Center for Kampo Medicine, Keio University School of Medicine
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WATANABE Kenji
Center for Kampo Medicine, Keio University School of Medicine
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Miura Naoko
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Fukutake Masato
Tsumura Laboratory Tsumura & Co.
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Fukutake M
Central Research Laboratories Tsumura & Co.
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Ohtake Nobuhiro
Central Research Laboratories Tsumura & Co.
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竹田 秀一
Tsumura & Co. Tsumura Res. Laboratories
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Iizuka Seiichi
Central Laboratories Tsumura & Co.
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Nakai Yasuhiro
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
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Yamamoto Masako
Department Of Anatomy Ii School Of Veterinary Medicine Azabu University
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Fukutake Masato
Central Research Laboratories Tsumura & Co.
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Nakai Y
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラツムラ研究所
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Iizuka A
Central Research Laboratories Tsumura & Co
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Takeda Shuichi
Central Research Laboratories Tsumura & Co.
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Takeda Shuichi
Department Of Drug Metabolism & Disposition Tsumura Research Institute Tsumura & Co.
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Imamura Sachiko
Research Division Tsumura & Co.
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Tsuchiya Naoko
Central Research Laboratories Tsumura & Co.
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Ishimatsu Makoto
Central Research Laboratories Tsumura & Co.
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Iizuka Seiichi
Research Institute Of Pharmaceutical Sciences Musashino University
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Yamamoto Masaru
Laboratories Of Natural Information Science Graduate School Of Integrated Science Yokohama City Univ
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Watanabe Kenji
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Ohtake Nobuhiro
Tsumura Research Institute Tsumura & Co.
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Nakamura Yuichi
Pharmacognosy & Medicinal Resources Research Department
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Watanabe Kenji
Department Of Gastroenterology Graduate School Of Medicine Osaka City University
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Watanabe Kenji
Department Of Anatomy Fukui Medical School
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Yamamoto Masahiro
Center For Kampo Medicine Keio University School Of Medicine
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Watanabe Kenji
Center For Kampo Medicine Keio University School Of Medicine
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Watanabe Kenji
Department Of Agricultural Chemistry College Of Agriculture And Veterinary Medicine Nihon University
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Takeda Shuichi
Tsumura & Co. Tsumura Research Laboratories
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TSUCHIYA Naoko
Central Research Laboratories, Tsumura & Co.
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