Diabetic Complications in a New Animal Model (TSOD mouse) of Spontaneous NIDDM with Obesity
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概要
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The TSOD mouse has been established as an inbred strain with spontaneous development of diabetes mellitus as the first clinical signs of diabetes. Polydipsia and polyuria are observed at about 2 months old only in male mice, after which hyperglycemia and hyperinsulinemia are detected. Following these symptoms obesity gradually develops until about 12 months old. In histopathological examination of the pancreas, severe hypertrophy of pancreatic islets was observed due to proliferation and swelling of B cells. In the kidney, thickening of the basement membrane in glomeruli and an increase of the mesangial area were observed at 18 months old. Motor neuropathy in TSOD mice began to appear at 14 months old and most male mice at 17 months old showed weakness of front and hind paws caused by neuron degeneration in the peripheral nerve. In sensory neuropathy, the threshold in the tail pressure test decreased significantly at 12 months old. Light microscopic and electron microscopic examination of sciatic nerves showed a decrease in the density of nerve fibers by the endoneural fibrosis and loss of these fibers. Degenerative changes of myelinated fibers, separation of myelin sheaths with intralamellar edema and remyelination were frequently observed. In the severely affected nerve fibers, the lamellar structure was completely destroyed and macrophages migrated around the myelin sheath or invaded the intramyelin space. Considering these findings similar to non-insulin dependent diabetes mellitus (NIDDM) in humans, the TSOD mouse should be a useful model for the pathogenic study of diabetic complications, especially of peripheral neuropathy.
- 社団法人 日本実験動物学会の論文
- 2005-01-01
著者
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ABURADA Masaki
Research Division, Tsumura & Co.
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Yamaguchi Takuji
ツムラ中央研究所
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油田 正樹
Medicinal Evaluation Laboratory Tsumura Research Institute
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
ツムラ漢方生薬研究所
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Aburada M
Fac. Of Pharmacy Musashino Univ.
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Aburada M
Tsumura Research Inst. Pharmacology Ibaraki Jpn
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加瀬 義夫
津村薬理研究所
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IIZUKA Seiichi
Research Division, Tsumura & Co.
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SUZUKI Wataru
Research Division, Tsumura & Co.
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TABUCHI Masahiro
Research Division, Tsumura & Co.
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NAGATA Mitsunobu
Research Division, Tsumura & Co.
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IMAMURA Sachiko
Research Division, Tsumura & Co.
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KOBAYASHI Yujiro
Research Division, Tsumura & Co.
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KANITANI Masanao
Research Division, Tsumura & Co.
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YANAGISAWA Toshihiko
Research Division, Tsumura & Co.
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KASE Yoshio
Research Division, Tsumura & Co.
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TAKEDA Shuichi
Research Division, Tsumura & Co.
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TAKAHASHI Kazuaki
Department of Laboratory Animal Science, Nippon Veterinary & Animal Science University
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Yanagisawa T
New Drug Discovery Laboratories R&d Division Tsumura & Co. Ltd.
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Suzuki Wataru
Res. Inst. Of Pharmaceutical Sciences Musashino Univ.
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竹田 秀一
Tsumura & Co. Tsumura Res. Laboratories
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油田 正樹
ツムラ研究本部 医薬評価研究所
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Iizuka Seiichi
Central Laboratories Tsumura & Co.
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Kanitani Masanao
Tsumura&co.
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Takizawa Yukiho
Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo
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Yanagisawa Toshihiko
Tsumura&co.
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Yanagisawa Toshihiko
Central Research Laboratories Tsumura & Co.
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Suzuki Wataru
Department Of Microbiology Showa University School Of Pharmaceutical Sciences
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Kase Yoshio
ツムラツムラ研究所
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Imamura Sachiko
Research Division Tsumura & Co.
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Nakazawa Mikio
Dep. Of Medical Technol. School Of Health Sci. Fac. Of Medicine Niigata Univ.
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Iizuka Seiichi
Research Institute Of Pharmaceutical Sciences Musashino University
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Tabuchi Masahiro
Central Research Laboratories Research And Development Division Tsumura & Co.
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Tabuchi Masahiro
Research Anddevelopment Division Tsumura & Co.
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Kobayashi Yujiro
Research Division Tsumura & Co.
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Takahashi Kazuaki
Department Of Developmental Biology And Neurosciences Graduate School Of Life Sciences Tohoku Univer
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Takahashi Kazuaki
Department Of Laboratory Animal Science Nippon Veterinary & Animal Science University
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Takahashi Kazuaki
Department Of Animal Science Faculty Of Agriculture Tohoku University
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Tabuchi Masahiro
Research and Development Division, Tsumura & Co.
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