Effects of Hange-shashin-to on Cholera Toxin-Induced Fluid Secretion in the Small Intestine of Rats
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概要
- 論文の詳細を見る
The effects of Hange-shashin-to (TJ-14) on cholera toxin-induced intestinal fluid secretion were studied to elucidate the mechanism by which this kampo medicine manifests antidiarrheal effects. TJ-14 suppressed the intestinal fluid secretion induced by cholera toxin (1 μg/rat) in a dose-dependent manner at doses between 125 and 1000 mg/kg. It also inhibited the luminal prostaglandin E_2 (PGE_2) level. On the other hand, serotonin (5-HT) release was not affected by TJ-14. Subcutaneous injection of indomethacin at 10 mg/kg or ondansetron at 100 μg/kg significantly suppressed intestinal secretion. The luminal PGE_2 level was also inhibited by indomethacin (10 mg/kg, s.c.). TJ-14,even at 10^<-4> g/ml, and little effect on the phasic contration of isolated guinea pig ileum induced by 5-HT (2×10^<-6> g/ml), while ondansetron suppressed the phasic contraction caused by 5-HT.These results indicate that TJ-14 is useful in suppressing cholera toxin-stimulated intestinal fluid secretion, and that this effect is partially due to its suppressive action on the PGE_2 level.
- 社団法人日本薬学会の論文
- 1998-02-15
著者
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石毛 敦
(株)ツムラ中央研究所
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石毛 敦
株式会社ツムラ 研究本部 医薬評価研究所
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石毛 敦
ツムラ研究本部 医薬評価研究所
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ISHIGE Atsushi
株式会社ツムラ 研究本部 医薬評価研究所
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Kase Y
Tsumura Research Laboratories Tsumura & Co.
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Kase Yoshio
国立長寿医療センター研究所 老年病研究部
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Kase Yoshio
Central Research Laboratories Tsumura & Co.
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Kase Yoshio
Central Research Laboratory Tsumura & Co.
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Ishige A
Tsumura Res. Inst. Ibaraki Jpn
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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加瀬 義夫
津村薬理研究所
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YUZURIHARA Mitsutoshi
Central Research Laboratories, Tsumura & Co.
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ISHIGE Atsushi
Central Research Laboratories, Tsumura & Co.
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Yuzurihara Mitsutoshi
Tsumura Research Laboratories Tsumura & Co.
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Yuzurihara M
Tsumura Res. Inst. Medical Evaluation Lab. Ibaraki Jpn
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Yuzurihara Mitsutoshi
Central Research Laboratory Tsumura & Co.
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Yuzurihara Mitsutoshi
Kampo & Parmacognosy Laboratory Tsumura & Co.
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KOMATSU Yasuhiro
Central Research Laboratories, Tsumura & Co.
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SAITOH Kazuko
Central Research Laboratories, Tsumura and Co.,
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Ishige Atsushi
Central Research Laboratories Tsumura & Co
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Saito Kazuko
Kampo & Pharmacognosy Laboratory R & D Division Tsumura & Co.
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Komatsu Yasuhiro
Central Research Laboratories Tsumura & Co
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Mizuhara Yasuharu
Medicinal Evaluation Laboratory Tsumura & Co.:department Of Medicinal Informatics Graduate Schoo
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Iizuka A
Central Research Laboratories Tsumura & Co
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Saitoh K
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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