Inhibitory Effect of Coptidis Rhizoma and Scutellariae Radix on Azoxymethane-Induced Aberrant Crypt Foci Formation in Rat Colon
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概要
- 論文の詳細を見る
This study was conducted t obtain effective cancer chemopreventive agents with low toxicity from medicinal herbs. The effect of aqueous extracts from 9 medicinal herbs with anti inflammatory effect were examined on the formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF), putative preneoplastic lesions of the colon. Male F344 rats were treated with 15 mg/kg body weight of AOM once a week for two weeks. Herbal extract consisting of 2% of the diet was administered from 1 d prior to the first carcinogen treatment. The number of AOM-induced ACF per colon was counted at 4 week. Extracts of Coptidis Rhizoma and Scutellariae Radix significantly inhibited AOM-induced ACF formation. The number of ACF was decreased to 54% and 78% of that of the control by 2% Coptidis Rhizoma and Scutellariae Radix extract in the diet, respectively. Berberine and Baicalin, major ingredients of Coptideis Rhizoma and Scutellariae Radix, inhibited ACF formation at a dose equivalent to the amount in each herbal extract.Therefore, to investigte the mechanisms of action of berberine and baicalein which is the active substances of orally administered baicalin, their effects on cyclooxygenase 1 and 2 activities were studied. Berberine was found to inhibit cyclooxygenase 2 activity without inhibition of cyclooxygenase 1 activity, and baicalein inhibited cyclooxygenase 1 activity.Thus, Coptidis Rhizoma and Scutellariae Radix suppressed experimental colon carcinogenesis, and their chemopreventive effects were explained from the inhibition of berberine on cyclooxygenase 2 activity and baicalein on cyclooxygenase 1 activity.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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Komatsu Yasuhiro
北陸大学 薬 薬物治療
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Ishige Atsushi
Center For Kampo Medicine Keio University School Of Medicine
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Ishige Atsushi
北陸大学 薬 薬物治療
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Ishige Atsushi
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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FUKUTAKE Masato
Central Research Laboratories, Tsumura & Co.
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KOMATSU Yasuhiro
Central Research Laboratories, Tsumura & Co.
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Ishige Atsushi
Kampo Pharmacology Department Ii Pharmacognosy Laboratory
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Komatsu Y
Tsumura Central Research Laboratories Tsumura And Co.
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Komatsu Y
Central Research Laboratories Tsumura & Co
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Komatsu Yasuhiro
Department Of Serology Kanazawa Medical University
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Fukutake Masato
Tsumura Laboratory Tsumura & Co.
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Fukutake M
Central Research Laboratories Tsumura & Co.
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KAWAMURA Hideki
Central Laboratories, Tsumura & Co.
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Fukuda K
Central Research Laboratories Tsumura & Co.
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YOKOTA Shigeru
Laboratory of Molecular Biology School of Hygenic Sciences, Kitasato University
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IIZUKA Akira
Central Research Laboratories, Tsumura & Co.
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AMAGAYA Sakae
Central Research Laboratories, Tsumura & Co.
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FUKUDA Kazunori
Central Research Laboratories, Tsumura & Co.
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Fukutake Masato
Central Research Laboratories Tsumura & Co.
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Komatsu Yasuhiro
Central Research Laboratories Tsumura & Co
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Komatsu Y
Kampo And Pharmacognosy Laboratories Tsumura & Co.
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Iizuka A
Central Research Laboratories Tsumura & Co
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Amagaya S
Central Research Laboratories Tsumura & Co
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Amagaya Sakae
Central Research Laboratories Tsumura & Co.
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Amagaya Sakae
Pharmacognosy And Medicical Resources Laboratories Tsumura Research Institute Tsumura & Co.
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Fukuda Kazunori
Central Research Laboratories Tsumura & Co.
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Yokota Shigeru
Laboratory Of Molecular Biology School Of Hygenic Sciences Kitasato University
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Komatsu Y
Res. Center Eishogen Co. Ltd. Saitama Jpn
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Kawamura Hideki
Central Research Laboratories Tsumura & Co.
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Kawamura Hideki
Central Laboratories Tsumura & Co.
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